Evidence map›Paper›PMID 14520439›Full record

ArticleBritish journal of cancer2003

CD40-targeted adenoviral GM-CSF gene transfer enhances and prolongs the maturation of human CML-derived dendritic cells upon cytokine deprivation.

A G M Stam, S J A M Santegoets, T M Westers, C C Sombroek, J J W M Janssen, B W Tillman, A A van de Loosdrecht, H M Pinedo, D T Curiel, G J Ossenkoppele and 2 more

Abstract read
In one paragraph

Article in British journal of cancer, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

A G M StamDepartment of Pathology, Free University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands.
S J A M Santegoets
T M Westers
C C Sombroek
J J W M Janssen
B W Tillman
A A van de Loosdrecht
H M Pinedo
D T Curiel
G J Ossenkoppele
R J Scheper
T D de Gruijl

Funding

UAB Rexinoids for Breast Cancer PreventionP50CA089019 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BLAND, KIRBY I. · 2000 to 2011
$26.0M
RESTORATION OF TCR REPERTOIRE AFTER DEPLETIONU19DK057958 · NIDDK · UNIVERSITY OF MINNESOTA · PI HERING, BERNHARD JOSEF · 1999 to 2006
$12.2M
Endothelial Gene Delivery for Pulmonary HypertensionR01HL067962 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CURIEL, DAVID TERRY · 2001 to 2004
$1.5M
DENDRITIC CELL SPECIFIC VECTORR01CA086881 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CURIEL, DAVID TERRY · 2000 to 2004
$1.1M
NCI NIH HHS P50 CA089019NCI NIH HHS P50 CA89019NCI NIH HHS R01 CA086881NCI NIH HHS R01 CA86881NHLBI NIH HHS R01 HL067962NHLBI NIH HHS R01 HL67962NIDDK NIH HHS U19 DK057958NIDDK NIH HHS U19 DK57958
6 · The paper itself

Abstract

Vaccination with autologous leukaemia-derived dendritic cells (DC) presents an adjuvant treatment option for chronic myeloid leukaemia (CML). Here, we show that high-efficiency CD40-targeted adenoviral gene transfer of GM-CSF to CML-derived DC induces long-lived maturation in the absence of exogenous cytokines and may thus ensure protracted stimulation of CML-specific T cells upon vaccination.

Indexed as

AdenoviridaeCD40 AntigensCytokinesDendritic CellsGenetic VectorsGene Transfer TechniquesGranulocyte-Macrophage Colony-Stimulating FactorHumansImmunophenotypingLeukemia, Myelogenous, Chronic, BCR-ABL PositiveT-Lymphocytes, CytotoxicTransduction, GeneticTumor Cells, CulturedCD40 AntigensCytokinesGranulocyte-Macrophage Colony-Stimulating Factor

Identifiers

PMID14520439
PMCPMC2394320

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.