ArticleEmerging infectious diseases2003
DNA vaccine for West Nile virus infection in fish crows (Corvus ossifragus).
Article in Emerging infectious diseases, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 76 citations in OpenAlex.
- Comparative efficacies of three commercially available vaccines against West Nile Virus (WNV) in a short-duration challenge trial involving an equine WNV encephalitis model.Clinical and vaccine immunology : CVI · 2007Trial
- Mucosal Vaccination: A Promising Alternative Against Flaviviruses.Frontiers in cellular and infection microbiology · 2022Review
- The Key Role of Nucleic Acid Vaccines for One Health.Viruses · 2021Review
- Impact of West Nile Virus on Bird Populations: Limited Lasting Effects, Evidence for Recovery, and Gaps in Our Understanding of Impacts on Ecosystems.Journal of medical entomology · 2019Review
- Current Progress of Avian Vaccines Against West Nile Virus.Vaccines · 2019Review
- Review
- A Recombinant Subviral Particle-Based Vaccine Protects Magpie (Frontiers in microbiology · 2019Article
- Evaluation of Cross-Protection of a Lineage 1 West Nile Virus Inactivated Vaccine against Natural Infections from a Virulent Lineage 2 Strain in Horses, under Field Conditions.Clinical and vaccine immunology : CVI · 2015Article
- DNA vaccines encoding the envelope protein of West Nile virus lineages 1 or 2 administered intramuscularly, via electroporation and with recombinant virus protein induce partial protection in large falcons (Falco spp.).Veterinary research · 2015Article
- Improvement of DNA vaccination by adjuvants and sophisticated delivery devices: vaccine-platforms for the battle against infectious diseases.Clinical and experimental vaccine research · 2015Review
- Seroepidemiologic Survey of Potential Pathogens in Obligate and Facultative Scavenging Avian Species in California.PloS one · 2015Article
- Limited efficacy of West Nile virus vaccines in large falcons (Falco spp.).Veterinary research · 2014Article
- The dichotomy of pathogens and allergens in vaccination approaches.Frontiers in microbiology · 2014Review
- Flaviviruses in Europe: complex circulation patterns and their consequences for the diagnosis and control of West Nile disease.International journal of environmental research and public health · 2013Review
- A review of vaccine approaches for West Nile virus.International journal of environmental research and public health · 2013Review
- Efficacy of three vaccines in protecting Western Scrub-Jays (Aphelocoma californica) from experimental infection with West Nile virus: implications for vaccination of Island Scrub-Jays (Aphelocoma insularis).Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2011Article
- DNA vaccination of American robins (Turdus migratorius) against West Nile virus.Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2010Article
- West nile virus: characteristics of an african virus adapting to the third millennium world.The open virology journal · 2010Article
- West Nile virus and hemoparasites in captive snowy owls (Bubo scandiacus)--management strategies to optimize survival.The Canadian veterinary journal = La revue veterinaire canadienne · 2008Article
- The relative contribution of antibody and CD8+ T cells to vaccine immunity against West Nile encephalitis virus.Vaccine · 2008Article
Corrections and comments
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Authors and funding
14 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A DNA vaccine for West Nile virus (WNV) was evaluated to determine whether its use could protect fish crows (Corvus ossifragus) from fatal WNV infection. Captured adult crows were given 0.5 mg of the DNA vaccine either orally or by intramuscular (IM) inoculation; control crows were inoculated or orally exposed to a placebo. After 6 weeks, crows were challenged subcutaneously with 105 plaque-forming units of WNV (New York 1999 strain). None of the placebo inoculated-placebo challenged birds died. While none of the 9 IM vaccine-inoculated birds died, 5 of 10 placebo-inoculated and 4 of 8 orally vaccinated birds died within 15 days after challenge. Peak viremia titers in birds with fatal WNV infection were substantially higher than those in birds that survived infection. Although oral administration of a single DNA vaccine dose failed to elicit an immune response or protect crows from WNV infection, IM administration of a single dose prevented death and was associated with reduced viremia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.