ArticleGenome biology2003
Time- and exercise-dependent gene regulation in human skeletal muscle.
Article in Genome biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
125 citing papers in PubMed, 3 syntheses or guidelines pooled it, 254 citations in OpenAlex.
- Time-Dependent Effects of Physical Activity on Cardiovascular Risk Factors in Adults: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Do exercise-associated genes explain phenotypic variance in the three components of fitness? a systematic review & meta-analysis.PloS one · 2021Pooled it
- Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity.Nature communications · 2020Pooled it
- The relationship between circadian type and physical activity as predictors of cognitive performance during simulated nightshifts: A randomised controlled trial.Chronobiology international · 2025Trial
- Skeletal muscle gene expression in response to resistance exercise: sex specific regulation.BMC genomics · 2010Trial
- Eccentric exercise activates novel transcriptional regulation of hypertrophic signaling pathways not affected by hormone changes.PloS one · 2010Trial
- Restoration of circadian rhythm as novel targets against sarcopenia.Chinese medical journal · 2026Review
- The Cardiac Circadian Clock Regulates Rhythms in Peripheral Tissues via Fibulin 5.Comprehensive physiology · 2026Article
- Opportunities for RNA sequencing in physiology: from big data to understanding homeostasis and heterogeneity.Function (Oxford, England) · 2026Review
- Article
- Exercise and sleep health in college students: Efficacy, mechanisms, and implications for practice.World journal of psychiatry · 2025Review
- Circadian Phase Determines Tissue-Specific Adaptations to Long-Term Exercise in Obese Mice.Nutrients · 2025Article
- Clock Gene Expression Modulation by Low- and High-Intensity Exercise Regimens in Aging Mice.International journal of molecular sciences · 2025Article
- Circadian clock and its effect on aging and lifespan.Biogerontology · 2025Review
- Advancing Chrononutrition for Cardiometabolic Health: A 2023 National Heart, Lung, and Blood Institute Workshop Report.Journal of the American Heart Association · 2025Review
- Role of the tendon circadian clock in tendinopathy and implications for therapeutics.International journal of experimental pathology · 2025Review
- NOR-1 Overexpression Elevates Myoglobin Expression via PERM1 and Enhances Mitochondrial Function and Endurance in Skeletal Muscles of Aged Mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Resistance but not endurance training suppresses glucocorticoid-induced leucine zipper (GILZ) expression in human skeletal muscle.European journal of applied physiology · 2025Article
- A primer on global molecular responses to exercise in skeletal muscle: Omics in focus.Journal of sport and health science · 2025Review
- Diurnal variation in skeletal muscle mitochondrial function dictates time-of-day-dependent exercise capacity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
65 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundSkeletal muscle remodeling is a critical component of an organism's response to environmental changes. Exercise causes structural changes in muscle and can induce phase shifts in circadian rhythms, fluctuations in physiology and behavior with a period of around 24 hours that are maintained by a core clock mechanism. Both exercise-induced remodeling and circadian rhythms rely on the transcriptional regulation of key genes.
resultsWe used DNA microarrays to determine the effects of resistance exercise (RE) on gene regulation in biopsy samples of human quadriceps muscle obtained 6 and 18 hours after an acute bout of isotonic exercise with one leg. We also profiled diurnal gene regulation at the same time points (2000 and 0800 hours) in the non-exercised leg. Comparison of our results with published circadian gene profiles in mice identified 44 putative genes that were regulated in a circadian fashion. We then used quantitative PCR to validate the circadian expression of selected gene orthologs in mouse skeletal muscle.
conclusionsThe coordinated regulation of the circadian clock genes Cry1, Per2, and Bmal1 6 hours after RE and diurnal genes 18 hours after RE in the exercised leg suggest that RE may directly modulate circadian rhythms in human skeletal muscle.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.