ArticleThe Biochemical journal2003
Evidence for the transport of glutathione through ryanodine receptor channel type 1.
Article in The Biochemical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Endoplasmic Reticulum Redoxome: Protein Folding and Beyond.Biochemistry · 2026Review
- Review
- Pravastatin induces NO synthesis by enhancing microsomal arginine uptake in healthy and preeclamptic placentas.BMC pregnancy and childbirth · 2019Article
- Redox-Mediated Regulatory Mechanisms of Endoplasmic Reticulum Homeostasis.Cold Spring Harbor perspectives in biology · 2019Review
- Redox Signaling by Reactive Electrophiles and Oxidants.Chemical reviews · 2018Review
- Glutathione: Antioxidant Properties Dedicated to Nanotechnologies.Antioxidants (Basel, Switzerland) · 2018Review
- Glutathione in Cellular Redox Homeostasis: Association with the Excitatory Amino Acid Carrier 1 (EAAC1).Molecules (Basel, Switzerland) · 2015Review
- Molecular targeting of proteins by L-homocysteine: mechanistic implications for vascular disease.Antioxidants & redox signaling · 2007Review
- A musculoskeletal model of low grade connective tissue inflammation in patients with thyroid associated ophthalmopathy (TAO): the WOMED concept of lateral tension and its general implications in disease.BMC musculoskeletal disorders · 2007Article
- The role of glutathione in disulphide bond formation and endoplasmic-reticulum-generated oxidative stress.EMBO reports · 2006Review
- Genetic and environmental factors influencing glutathione homeostasis in Saccharomyces cerevisiae.Molecular biology of the cell · 2005Article
- Plasma membrane glutathione transporters and their roles in cell physiology and pathophysiology.Molecular aspects of medicineReview
- Environmental toxicity, redox signaling and lung inflammation: the role of glutathione.Molecular aspects of medicineReview
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present study, we have investigated the role of RyR1 (ryanodine receptor calcium channel type 1) in glutathione (GSH) transport through the sarcoplasmic reticulum (SR) membrane of skeletal muscles. Lanthanum chloride, a prototypic blocker of cation channels, inhibited the influx and efflux of GSH in SR vesicles. Using a rapid-filtration-based assay and lanthanum chloride as a transport blocker, an uptake of radiolabelled GSH into SR vesicles was observed. Pretreatment of SR vesicles with the RyR1 antagonists Ruthenium Red and ryanodine as well as with lanthanum chloride blocked the GSH uptake. An SR-like GSH uptake appeared in microsomes obtained from an HEK-293 (human embryonic kidney 293) cell line after transfection of RyR1. These observations strongly suggest that RyR1 mediates GSH transport through the SR membranes of skeletal muscles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.