ArticleJournal of biomedical materials research. Part A2003
Cementum engineering with three-dimensional polymer scaffolds.
Article in Journal of biomedical materials research. Part A, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 76 citations in OpenAlex.
- Heterogeneous dental follicle cells and the regeneration of complex periodontal tissues.Tissue engineering. Part A · 2012Trial
- Breaking Barriers: Evaluating Challenges in Advancing Periodontal Ligament Cell-Derived Organoids.Dentistry journal · 2025Review
- Biological processes and factors involved in soft and hard tissue healing.Periodontology 2000 · 2025Review
- A conceptual review on reconstructive peri-implantitis therapy: Challenges and opportunities.Clinical and experimental dental research · 2023Review
- Hard Dental Tissues Regeneration-Approaches and Challenges.Materials (Basel, Switzerland) · 2021Review
- Biomaterial-Based Approaches for Regeneration of Periodontal Ligament and Cementum Using 3D Platforms.International journal of molecular sciences · 2019Review
- Overlapping functions of bone sialoprotein and pyrophosphate regulators in directing cementogenesis.Bone · 2017Article
- Poly(Lactic-co-Glycolic Acid): Applications and Future Prospects for Periodontal Tissue Regeneration.Polymers · 2017Review
- Advanced biomatrix designs for regenerative therapy of periodontal tissues.Journal of dental research · 2014Review
- Surgical Approaches Based on Biological Objectives: GTR versus GBR Techniques.International journal of dentistry · 2013Article
- Bone repair cells for craniofacial regeneration.Advanced drug delivery reviews · 2012Review
- Coculture strategies in bone tissue engineering: the impact of culture conditions on pluripotent stem cell populations.Tissue engineering. Part B, Reviews · 2012Review
- Methods to validate tooth-supporting regenerative therapies.Methods in molecular biology (Clifton, N.J.) · 2012Article
- Cell- and gene-based therapeutic strategies for periodontal regenerative medicine.Journal of periodontology · 2011Review
- Tissue engineering: state of the art in oral rehabilitation.Journal of oral rehabilitation · 2009Review
- Nanofibrous scaffolds incorporating PDGF-BB microspheres induce chemokine expression and tissue neogenesis in vivo.PloS one · 2008Article
- Three-dimensional micro-computed tomographic imaging of alveolar bone in experimental bone loss or repair.Journal of periodontology · 2007Article
- Craniofacial tissue engineering by stem cells.Journal of dental research · 2006Review
- Dental follicle progenitor cell heterogeneity in the developing mouse periodontium.Stem cells and development · 2006Article
- Effect of sustained gene delivery of platelet-derived growth factor or its antagonist (PDGF-1308) on tissue-engineered cementum.Journal of periodontology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Cloned cementoblasts (OCCMs), periodontal ligament fibroblasts (SV-PDLs), and dental follicle (SV-F) cells obtained from mice were used as a tool to study periodontal tissue engineering. OCCM, SV-PDL, and SV-F cells were seeded onto three-dimensional poly lactic-co-glycolic acid (PLGA) scaffolds and cultured with the use of bioreactors or implanted subcutaneously in severe combined immune deficiency (SCID) mice for up to 6 weeks. We explored the behavior of these cells in porous PLGA sponges by cell growth, expression of mineral-associated genes using reverse transcriptase polymerase chain reaction, and mineralization by histologic analysis in vitro and in vivo. Results indicated that cells attached to PLGA scaffolds under either static or dynamic conditions in vitro. Only OCCM implants, retrieved from both in vitro bioreactors and SCID mice at 3-and 6-weeks post-cell implantation exhibited mineral formation. Types I and XII collagens, osteocalcin, and bone sialoprotein genes were detected in all implants retrieved from SCID mice. These results suggest that delivery of selected cells via PLGA scaffolds may serve as a viable approach for promoting periodontal tissue regeneration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.