ArticleNature genetics2003
A natural allele of Nxf1 suppresses retrovirus insertional mutations.
Article in Nature genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Mammalian START-like phosphatidylinositol transfer proteins - Physiological perspectives and roles in cancer biology.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2024Review
- CRISPR/Cas9 mediated somatic gene therapy for insertional mutations: thePrecision clinical medicine · 2021Article
- Lipid transfer proteins and instructive regulation of lipid kinase activities: Implications for inositol lipid signaling and disease.Advances in biological regulation · 2020Review
- Chromatin-associated RNAs as facilitators of functional genomic interactions.Nature reviews. Genetics · 2019Review
- Zfp423 Regulates Sonic Hedgehog Signaling via Primary Cilium Function.PLoS genetics · 2016Article
- Nmf9 Encodes a Highly Conserved Protein Important to Neurological Function in Mice and Flies.PLoS genetics · 2015Article
- Contrasting genetic architectures in different mouse reference populations used for studying complex traits.Genome research · 2015Review
- Nxf1 natural variant E610G is a semi-dominant suppressor of IAP-induced RNA processing defects.PLoS genetics · 2015Article
- Zfp423 binds autoregulatory sites in p19 cell culture model.PloS one · 2013Article
- Modifier genes and the plasticity of genetic networks in mice.PLoS genetics · 2012Review
- Modifier genes and non-genetic factors reshape anatomical deficits in Zfp423-deficient mice.Human molecular genetics · 2011Article
- A missense mutation in Fgfr1 causes ear and skull defects in hush puppy mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Article
- Modifier genes for mouse phosphatidylinositol transfer protein α (vibrator) that bypass juvenile lethality.Genetics · 2011Article
- Mammalian diseases of phosphatidylinositol transfer proteins and their homologs.Clinical lipidology · 2010Article
- Multipotent genetic suppression of retrotransposon-induced mutations by Nxf1 through fine-tuning of alternative splicing.PLoS genetics · 2009Article
- Mapping of genetic modifiers of Eya1 ( bor/bor ) in CAST/EiJ and BALB/cJ that suppress cochlear aplasia and associated deafness.Mammalian genome : official journal of the International Mammalian Genome Society · 2008Article
- The impact of alternative splicing in vivo: mouse models show the way.RNA (New York, N.Y.) · 2007Review
- Retroviral elements and their hosts: insertional mutagenesis in the mouse germ line.PLoS genetics · 2006Article
- Contribution of Asian mouse subspecies Mus musculus molossinus to genomic constitution of strain C57BL/6J, as defined by BAC-end sequence-SNP analysis.Genome research · 2004Article
- The insertional history of an active family of L1 retrotransposons in humans.Genome research · 2004Article
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14 authors at 6 institutions in 3 countries.
Funding
Abstract
Endogenous retroviruses have shaped the evolution of mammalian genomes. Host genes that control the effects of retrovirus insertions are therefore of great interest. The modifier-of-vibrator-1 locus (Mvb1) controls levels of correctly processed mRNA from genes mutated by endogenous retrovirus insertions into introns, including the Pitpn(vb) tremor mutation and the Eya1(BOR) model of human branchiootorenal syndrome. Positional complementation cloning identifies Mvb1 as the nuclear export factor Nxf1, providing an unexpected link between the mRNA export receptor and pre-mRNA processing. Population structure of the suppressive allele in wild Mus musculus castaneus suggests selective advantage. A congenic Mvb1(CAST) allele is a useful tool for modifying gene expression from existing mutations and could be used to manipulate engineered mutations containing retroviral elements.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.