ArticleMolecular biology of the cell2003
Conserved function of pex11p and the novel pex25p and pex27p in peroxisome biogenesis.
Article in Molecular biology of the cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- PEX11 mediates intralumenal vesicle formation in peroxisomes.Nature communications · 2026Article
- ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway.Nature chemical biology · 2025Article
- Convergent and divergent mechanisms of peroxisomal and mitochondrial division.The Journal of cell biology · 2023Article
- The dynamin-related protein Vps1 and the peroxisomal membrane protein Pex27 function together during peroxisome fission.Journal of cell science · 2023Article
- Molecular basis of the glycosomal targeting of PEX11 and its mislocalization to mitochondrion in trypanosomes.Frontiers in cell and developmental biology · 2023Article
- Peroxisome biogenesis and inter-organelle communication: an indispensable role for Pex11 and Pex30 family proteins in yeast.Current genetics · 2022Review
- Peroxisome Proliferator FpPEX11 Is Involved in the Development and Pathogenicity inInternational journal of molecular sciences · 2022Article
- The MyLO CRISPR-Cas9 toolkit: a markerless yeast localization and overexpression CRISPR-Cas9 toolkit.G3 (Bethesda, Md.) · 2022Article
- Increased peroxisome proliferation is associated with early yeast replicative ageing.Current genetics · 2022Article
- Peroxisome function relies on organelle-associated mRNA translation.Science advances · 2022Article
- Determinants of Peroxisome Membrane Dynamics.Frontiers in physiology · 2022Review
- Overexpression of the peroxin Pex34p suppresses impaired acetate utilization in yeast lacking the mitochondrial aspartate/glutamate carrier Agc1p.FEMS yeast research · 2019Article
- Plant peroxisomal solute transporter proteins.Journal of integrative plant biology · 2019Review
- Functional regions of the peroxin Pex19 necessary for peroxisome biogenesis.The Journal of biological chemistry · 2017Article
- Super-resolution Microscopy Reveals Compartmentalization of Peroxisomal Membrane Proteins.The Journal of biological chemistry · 2016Article
- Peroxins Pex30 and Pex29 Dynamically Associate with Reticulons to Regulate Peroxisome Biogenesis from the Endoplasmic Reticulum.The Journal of biological chemistry · 2016Article
- Giant peroxisomes in a moss (Physcomitrella patens) peroxisomal biogenesis factor 11 mutant.The New phytologist · 2016Article
- Genome-Wide Localization Study of Yeast Pex11 Identifies Peroxisome-Mitochondria Interactions through the ERMES Complex.Journal of molecular biology · 2015Article
- Role of Pex11p in Lipid Homeostasis in Yarrowia lipolytica.Eukaryotic cell · 2015Article
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4 authors.
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Abstract
We describe the isolation and characterization of a homologous pair of proteins, Pex25p (YPL112c) and Pex27p (YOR193w), whose C-termini are similar to the entire Pex11p. All three proteins localize to the peroxisomal membrane and are likely to form homo-oligomers. Deletion of any of the three genes resulted in enlarged peroxisomes as revealed by fluorescence and electron microscopy. The partial growth defect on fatty acids of a pex25delta mutant was not exacerbated by the additional deletion of PEX27; however, when PEX11 was deleted on top of that, growth was abolished on all fatty acids. Moreover, a severe peroxisomal protein import defect was observed in the pex11deltapex25deltapex27delta triple mutant strain. This import defect was also observed when cells were grown on ethanol-containing medium, where peroxisomes are not required, suggesting that the function of the proteins in peroxisome biogenesis exceeds their role in proliferation. When Pex25p was overexpressed in the triple mutant strain, growth on oleic acid was completely restored and a massive proliferation of laminar membranes and peroxisomes was observed. Our data demonstrate that Pex11p, Pex25p, and Pex27p build a family of proteins whose members are required for peroxisome biogenesis and play a role in the regulation of peroxisome size and number.
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