ArticleMolecular biology of the cell2003
Actin filament turnover regulated by cross-linking accounts for the size, shape, location, and number of actin bundles in Drosophila bristles.
Article in Molecular biology of the cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 44 citations in OpenAlex.
- The actin cytoskeleton plays multiple roles in structural colour formation in butterfly wing scales.Nature communications · 2024Article
- Tyrosyl-tRNA synthetase has a noncanonical function in actin bundling.Nature communications · 2023Article
- Plastin and spectrin cooperate to stabilize the actomyosin cortex during cytokinesis.Current biology : CB · 2021Article
- IKKε inhibits PKC to promote Fascin-dependent actin bundling.Development (Cambridge, England) · 2016Article
- Cofilin-mediated actin dynamics promotes actin bundle formation during Drosophila bristle development.Molecular biology of the cell · 2016Article
- Septin 9 Exhibits Polymorphic Binding to F-Actin and Inhibits Myosin and Cofilin Activity.Journal of molecular biology · 2015Article
- Fascin, may the Forked be with you.Fly · 2014Article
- β-Actin and fascin-2 cooperate to maintain stereocilia length.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins.Molecular biology of the cell · 2012Article
- Actin cross-linkers and the shape of stereocilia.Biophysical journal · 2010Article
- Cytoskeletal regulation of epithelial barrier function during inflammation.The American journal of pathology · 2010Review
- The Drosophila Fry protein interacts with Trc and is highly mobile in vivo.BMC developmental biology · 2010Article
- Asymmetric microtubule function is an essential requirement for polarized organization of the Drosophila bristle.Molecular and cellular biology · 2010Article
- Gamma-actin is required for cytoskeletal maintenance but not development.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Plastin 1 binds to keratin and is required for terminal web assembly in the intestinal epithelium.Molecular biology of the cell · 2009Article
- Dynamic length regulation of sensory stereocilia.Seminars in cell & developmental biology · 2008Review
- Deformations in actin comets from rocketing beads.Biophysical journal · 2006Article
- Capping protein and the Arp2/3 complex regulate nonbundle actin filament assembly to indirectly control actin bundle positioning during Drosophila melanogaster bristle development.Molecular biology of the cell · 2006Article
- Mutational analysis of Stubble-stubbloid gene structure and function in Drosophila leg and bristle morphogenesis.Genetics · 2006Article
- How to make a curved Drosophila bristle using straight actin bundles.Proceedings of the National Academy of Sciences of the United States of America · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Drosophila bristle cells are shaped during growth by longitudinal bundles of cross-linked actin filaments attached to the plasma membrane. We used confocal and electron microscopy to examine actin bundle structure and found that during bristle elongation, snarls of uncross-linked actin filaments and small internal bundles also form in the shaft cytoplasm only to disappear within 4 min. Thus, formation and later removal of actin filaments are prominent features of growing bristles. These transient snarls and internal bundles can be stabilized by culturing elongating bristles with jasplakinolide, a membrane-permeant inhibitor of actin filament depolymerization, resulting in enormous numbers of internal bundles and uncross-linked filaments. Examination of bundle disassembly in mutant bristles shows that plasma membrane association and cross-bridging adjacent actin filaments together inhibits depolymerization. Thus, highly cross-bridged and membrane-bound actin filaments turn over slowly and persist, whereas poorly cross-linked filaments turnover more rapidly. We argue that the selection of stable bundles relative to poorly cross-bridged filaments can account for the size, shape, number, and location of the longitudinal actin bundles in bristles. As a result, filament turnover plays an important role in regulating cytoskeleton assembly and consequently cell shape.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.