ArticleMolecular and cellular biology2003
TOR regulates the subcellular localization of Ime1, a transcriptional activator of meiotic development in budding yeast.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Nonessential kinetochore proteins contribute to meiotic chromosome condensation through polo-like kinase.Molecular biology of the cell · 2025Article
- Multi-signal regulation of the GSK-3β homolog Rim11 controls meiosis entry in budding yeast.The EMBO journal · 2024Article
- The transcriptional regulator Ume6 is a major driver of early gene expression during gametogenesis.Genetics · 2023Article
- Article
- Similar environments but diverse fates: Responses of budding yeast to nutrient deprivation.Microbial cell (Graz, Austria) · 2016Article
- Nutrient Control of Yeast Gametogenesis Is Mediated by TORC1, PKA and Energy Availability.PLoS genetics · 2016Article
- Retinoic acid activates two pathways required for meiosis in mice.PLoS genetics · 2014Article
- Dissecting the gene network of dietary restriction to identify evolutionarily conserved pathways and new functional genes.PLoS genetics · 2012Article
- Regulation of entry into gametogenesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Review
- Pleiotropic signaling pathways orchestrate yeast development.Current opinion in microbiology · 2011Review
- Mapping the interaction of Snf1 with TORC1 in Saccharomyces cerevisiae.Molecular systems biology · 2011Article
- Sporulation in the budding yeast Saccharomyces cerevisiae.Genetics · 2011Review
- Effects of age on meiosis in budding yeast.Developmental cell · 2009Article
- Glucose induction pathway regulates meiosis in Saccharomyces cerevisiae in part by controlling turnover of Ime2p meiotic kinase.FEMS yeast research · 2008Article
- Review
- The in vivo activity of Ime1, the key transcriptional activator of meiosis-specific genes in Saccharomyces cerevisiae, is inhibited by the cyclic AMP/protein kinase A signal pathway through the glycogen synthase kinase 3-beta homolog Rim11.Molecular and cellular biology · 2004Article
- The unfolded protein response represses differentiation through the RPD3-SIN3 histone deacetylase.The EMBO journal · 2004Article
- Glucose and nitrogen regulate the switch from histone deacetylation to acetylation for expression of early meiosis-specific genes in budding yeast.Molecular and cellular biology · 2004Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transcriptional activator Ime1 is a key regulator of meiosis and sporulation in budding yeast. Ime1 is controlled at different levels by nutrients and cell-type signals. Previously, we have proposed that G(1) cyclins would transmit nutritional signals to the Ime1 pathway by preventing the accumulation of Ime1 within the nucleus. We show here that nutritional signals regulate the subcellular localization of Ime1 through the TOR pathway. The inactivation of TOR with rapamycin promotes the nuclear accumulation and stabilization of Ime1, with consequent induction of early meiotic genes. On the contrary, the activation of TOR by glutamine induces the relocalization of Ime1 to the cytoplasm. Thus, TOR may sense optimal nitrogen- and carbon-limiting conditions to modulate Ime1 function. Besides TOR, ammonia induces an independent mechanism that prevents the accumulation of Ime1 in the nucleus. Both TOR and ammonia regulate Ime1 localization in the absence of Cdk1 activity and therefore use mechanisms different from those exerted by G(1) cyclins. Integration of independent mechanisms into a single early controlling step, such as the nuclear accumulation of Ime1, may help explain why yeast cells execute the meiotic program only when the appropriate internal and external conditions are met together.
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