ArticleMolecular and cellular biology2003
Core promoter elements and TAFs contribute to the diversity of transcriptional activation in vertebrates.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Overcoming the Silencing of Doxycycline-Inducible Promoters in hiPSC-derived Cardiomyocytes.Open research Europe · 2024Article
- Systematic interrogation of human promoters.Genome research · 2019Article
- Histone deacetylase 1 activates PU.1 gene transcription through regulating TAF9 deacetylation and transcription factor IID assembly.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- A Filtration-based Method of Preparing High-quality Nuclei from Cross-linked Skeletal Muscle for Chromatin Immunoprecipitation.Journal of visualized experiments : JoVE · 2017Article
- Core Promoter Plasticity Between Maize Tissues and Genotypes Contrasts with Predominance of Sharp Transcription Initiation Sites.The Plant cell · 2015Article
- p53 modulates the activity of the GLI1 oncogene through interactions with the shared coactivator TAF9.DNA repair · 2015Article
- Improved Tet-responsive promoters with minimized background expression.BMC biotechnology · 2010Article
- TIPT2 and geminin interact with basal transcription factors to synergize in transcriptional regulation.BMC biochemistry · 2009Article
- TFIIB recognition elements control the TFIIA-NC2 axis in transcriptional regulation.Molecular and cellular biology · 2009Article
- The 3' processing factor CstF functions in the DNA repair response.Nucleic acids research · 2008Article
- Variations in intracellular levels of TATA binding protein can affect specific genes by different mechanisms.Molecular and cellular biology · 2008Article
- TFIIB and the regulation of transcription by RNA polymerase II.Chromosoma · 2007Review
- Individual CREB-target genes dictate usage of distinct cAMP-responsive coactivation mechanisms.The EMBO journal · 2007Article
- Functional characterization of core promoter elements: the downstream core element is recognized by TAF1.Molecular and cellular biology · 2005Article
- A core promoter element downstream of the TATA box that is recognized by TFIIB.Genes & development · 2005Article
- Core promoter binding by histone-like TAF complexes.Molecular and cellular biology · 2005Article
- Specific TATAA and bZIP requirements suggest that HTLV-I Tax has transcriptional activity subsequent to the assembly of an initiation complex.Retrovirology · 2004Article
- The MTE, a new core promoter element for transcription by RNA polymerase II.Genes & development · 2004Article
- TFIIB-facilitated recruitment of preinitiation complexes by a TAF-independent mechanism.Nucleic acids research · 2004Article
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2 authors.
Funding
Abstract
Gene-specific transcriptional activation is a multistep process that requires numerous protein factors and DNA elements, including enhancers and the core promoter. To investigate the roles of core promoter elements in transcriptional activation in vertebrates, we examined expression and factor occupancy on representative promoters in chicken DT40 cells containing a conditional TATA binding protein (TBP)-associated factor 9 allele (TAF9). Characterized core elements, including TATA box-flanking regions and the downstream promoter element, were found to play significant roles in determining promoter strength, response to activators, and factor occupancy and recruitment. The requirement for TAF9 was found to be highly promoter specific, and TAF9 dependence and promoter occupancy were not always correlated. We also describe contrasting examples of factor recruitment and activation mechanisms at different promoters, highlighted by the nearly opposite mechanisms utilized by the simian virus 40 enhancer and p53. With the core promoters analyzed, the former functions by facilitating RNA polymerase II (RNAP II) recruitment to a preassembled TBP/TFIIB-containing scaffold and p53 strongly recruits TBP and TFIIB while RNAP II levels remain modest. Taken together, our results illustrate both the important roles of core promoter elements and the remarkable diversity that characterizes transcriptional activation mechanisms in vertebrates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.