ArticleMolecular and cellular biology2003
Prox1 is a novel coregulator of Ff1b and is involved in the embryonic development of the zebra fish interrenal primordium.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 67 citations in OpenAlex.
- Modeling Podocyte Ontogeny and Podocytopathies with the Zebrafish.Journal of developmental biology · 2023Review
- A fish with no sex: gonadal and adrenal functions partition between zebrafish NR5A1 co-orthologs.Genetics · 2021Article
- Visualizing the Interrenal Steroidogenic Tissue and Its Vascular Microenvironment in Zebrafish.Journal of visualized experiments : JoVE · 2016Article
- The endoderm indirectly influences morphogenetic movements of the zebrafish head kidney through the posterior cardinal vein and VegfC.Scientific reports · 2016Article
- Dedifferentiation of neurons precedes tumor formation in Lola mutants.Developmental cell · 2014Article
- Zebrafish yap1 plays a role in differentiation of hair cells in posterior lateral line.Scientific reports · 2014Article
- Osmotic regulation of seamless tube growth.Nature cell biology · 2013Article
- Lymphatic reprogramming by Kaposi sarcoma herpes virus promotes the oncogenic activity of the virus-encoded G-protein-coupled receptor.Cancer research · 2012Article
- Prox1 regulates the notch1-mediated inhibition of neurogenesis.PLoS biology · 2010Article
- prox1b Activity is essential in zebrafish lymphangiogenesis.PloS one · 2010Article
- Heterogeneity and plasticity of lymphatic endothelial cells.Seminars in thrombosis and hemostasis · 2010Review
- The nuclear hormone receptor Coup-TFII is required for the initiation and early maintenance of Prox1 expression in lymphatic endothelial cells.Genes & development · 2010Article
- The zebrafish prospero homolog prox1 is required for mechanosensory hair cell differentiation and functionality in the lateral line.BMC developmental biology · 2009Article
- Prox1 physically and functionally interacts with COUP-TFII to specify lymphatic endothelial cell fate.Blood · 2009Article
- Dual roles for Prox1 in the regulation of the chicken betaB1-crystallin promoter.Investigative ophthalmology & visual science · 2008Article
- Crucial role of zebrafish prox1 in hypothalamic catecholaminergic neurons development.BMC developmental biology · 2008Article
- PCNA interacts with Prox1 and represses its transcriptional activity.Molecular vision · 2008Article
- Localized rbp4 expression in the yolk syncytial layer plays a role in yolk cell extension and early liver development.BMC developmental biology · 2007Article
- Interrenal organogenesis in the zebrafish model.Organogenesis · 2007Article
- Characterization of a novel prospero-related homeobox gene, Prox2.Molecular genetics and genomics : MGG · 2006Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Steroidogenic factor 1 (SF-1) plays an essential role in adrenal development, although the exact molecular mechanisms are unclear. Our previous work established that Ff1b is the zebra fish homologue of SF-1 and that its disruption by antisense morpholinos leads to a complete ablation of the interrenal organ. In this study, results of biochemical analyses suggest that Ff1b and other Ff1 members interact with Prox1, a homeodomain protein. Fine mapping using site-directed mutants showed that this interaction requires an intact Ff1b heptad 9 and AF2, as well as Prox1 NR Box I. In vivo, this physical interaction led to the inhibition of Ff1-mediated transactivation of pLuc3XFRE, indicating that Prox1 acts to repress the transcriptional activity of Ff1b. In situ hybridization demonstrates that prox1 colocalizes with ff1a and ff1b in the liver and interrenal primordia, respectively. Embryos microinjected with prox1 morpholino displayed a consistent partial reduction of 3 eta-Hsd activity in the interrenal organ, while ff1b morpholino led to a disappearance of prox1. Based on these results, we propose that during the course of interrenal organogenesis, Prox1 functions as a tissue-specific coregulator of Ff1b and that the subsequent inhibition of Ff1b activity, after its initial roles in the specification of interrenal primordium, is critical for the maturation of the interrenal organ.
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