ArticleThe EMBO journal2003
Transglutaminase 2 inhibits Rb binding of human papillomavirus E7 by incorporating polyamine.
Article in The EMBO journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 59 citations in OpenAlex.
- Transglutaminase 2 regulates innate immunity: mechanisms and therapeutic implications.Oncoimmunology · 2026Review
- Molecular Basis of Transglutaminase-2 and Muscarinic Cholinergic Receptors in Experimental Myopia: A Target for Myopia Treatment.Biomolecules · 2023Article
- Double-Stranded RNA Enhances Matrix Metalloproteinase-1 and -13 Expressions through TLR3-Dependent Activation of Transglutaminase 2 in Dermal Fibroblasts.International journal of molecular sciences · 2022Article
- Transglutaminase 2 mediates transcriptional regulation through BAF250a polyamination.Genes & genomics · 2021Article
- The human papillomavirus oncoproteins: a review of the host pathways targeted on the road to transformation.The Journal of general virology · 2021Review
- Keratinocyte transglutaminase 2 promotes CCR6Cell death & disease · 2020Article
- Transglutaminase 2 mediates hypoxia-induced selective mRNA translation via polyamination of 4EBPs.Life science alliance · 2020Article
- Alterations in oral bacterial communities are associated with risk factors for oral and oropharyngeal cancer.Scientific reports · 2017Article
- Transglutaminase 2 mediates UV-induced skin inflammation by enhancing inflammatory cytokine production.Cell death & disease · 2017Article
- Endoplasmic reticulum stress activates transglutaminase 2 leading to protein aggregation.International journal of molecular medicine · 2014Article
- Intimal hyperplasia in loop-injured carotid arteries is attenuated in transglutaminase 2-null mice.Journal of Korean medical science · 2014Article
- Transglutaminase 2 as a novel activator of LRP6/β-catenin signaling.Cellular signalling · 2013Article
- The papillomavirus E7 proteins.Virology · 2013Review
- Transglutaminase is a therapeutic target for oxidative stress, excitotoxicity and stroke: a new epigenetic kid on the CNS block.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2013Review
- Transglutaminase 2 overexpression in tumor stroma identifies invasive ductal carcinomas of breast at high risk of recurrence.PloS one · 2013Article
- Differential alternative splicing of human transglutaminase 4 in benign prostate hyperplasia and prostate cancer.Experimental & molecular medicine · 2010Article
- Transglutaminase 2 suppresses apoptosis by modulating caspase 3 and NF-kappaB activity in hypoxic tumor cells.Oncogene · 2010Article
- Tissue transglutaminase 2 as a biomarker of cervical intraepithelial neoplasia (CIN) and its relationship to p16INK4A and nuclear factor kappaB expression.Virchows Archiv : an international journal of pathology · 2010Article
- Epigallocatechin-3-gallate enhances CD8+ T cell-mediated antitumor immunity induced by DNA vaccination.Cancer research · 2007Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transglutaminase 2 (TGase 2) is one of a family of enzymes that catalyze protein modification through the incorporation of polyamines into substrates or the formation of protein crosslinks. However, the physiological roles of TGase 2 are largely unknown. To elucidate the functions of TGase 2, we have searched for its interacting proteins. Here we show that TGase 2 interacts with E7 oncoprotein of human papillomavirus type 18 (HPV18) in vitro and in vivo. TGase 2 incorporates polyamines into a conserved glutamine residue in the zinc-binding domain of HPV18 E7 protein. This modification mediates the inhibition of E7's Rb binding ability. In contrast, TGase 2 does not affect HPV16 E7, due to absence of a glutamine residue at this polyamination site. Using E7 mutants, we demonstrate that TGase 2-dependent inhibition of HPV E7 function correlates with the presence of the polyamination site. Our results indicate that TGase 2 is an important cellular interfering factor and define a novel host-virus interaction, suggesting that the inability of TGase 2 to inactivate HPV16 E7 could explain the high prevalence of HPV16 in cervical cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.