ArticleThe EMBO journal2003
CIITA regulates transcription onset viaSer5-phosphorylation of RNA Pol II.
Article in The EMBO journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Epigenetic regulation of major histocompatibility complexes in gastrointestinal malignancies and the potential for clinical interception.Clinical epigenetics · 2024Pooled it
- Emerging roles of cyclin-dependent kinase 7 in health and diseases.Trends in molecular medicine · 2025Review
- A Ménage à trois: NLRC5, immunity, and metabolism.Frontiers in immunology · 2024Review
- Preclinical Characterization of Relatlimab, a Human LAG-3-Blocking Antibody, Alone or in Combination with Nivolumab.Cancer immunology research · 2022Article
- Targeting MHC Regulation Using Polycyclic Polyprenylated Acylphloroglucinols Isolated fromBiomolecules · 2020Article
- Morphology of nuclear transcription.Histochemistry and cell biology · 2016Review
- Overview of CDK9 as a target in cancer research.Cell cycle (Georgetown, Tex.) · 2016Review
- Metastatic melanoma cells evade immune detection by silencing STAT1.International journal of molecular sciences · 2015Article
- Article
- Regulation of MHC class I expression by Foxp3 and its effect on regulatory T cell function.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Gene-specific factors determine mitotic expression and bookmarking via alternate regulatory elements.Nucleic acids research · 2013Article
- Article
- Multiple histone methyl and acetyltransferase complex components bind the HLA-DRA gene.PloS one · 2012Article
- Novel functions for TAF7, a regulator of TAF1-independent transcription.The Journal of biological chemistry · 2010Article
- Epigenetic regulation of CD8(+) T-lymphocyte mediated suppression of HIV-1 replication.Virology · 2010Article
- Nonconventional initiation complex assembly by STAT and NF-kappaB transcription factors regulates nitric oxide synthase expression.Immunity · 2010Article
- Gamma interferon-dependent transcriptional memory via relocalization of a gene locus to PML nuclear bodies.Molecular and cellular biology · 2010Article
- Roles for common MLL/COMPASS subunits and the 19S proteasome in regulating CIITA pIV and MHC class II gene expression and promoter methylation.Epigenetics & chromatin · 2010Article
- Poised transcription factories prime silent uPA gene prior to activation.PLoS biology · 2010Article
- Modifications of RNA polymerase II are pivotal in regulating gene expression states.EMBO reports · 2009Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe the temporal order of recruitment of transcription factors, cofactors and basal transcriptional components and the consequent biochemical events that lead to activation of the major histocompatibility class II (MHCII) DRA gene transcription by IFN-gamma. We found that the gene is 'poised' for activation since both the activators and a fraction of the basal transcriptional machinery are pre-assembled at the enhancer and promoter prior to IFN-gamma treatment. The class II transactivator is synthesized following IFN-gamma treatment and it is recruited to the enhanceosome leading to the subsequent recruitment of the CBP and GCN5 coactivators. This is followed by histone acetylation and recruitment of the SWI/SNF chromatin remodeling complex. CIITA also recruits the CDK7 and CDK9 kinases and enhances the ability of CDK7 to phosphorylate Pol II at Ser5 leading to initiation of mRNA synthesis. Thus, the gene-specific class II transactivator selects the target genes for expression by coordinating a multiple set of biochemical activities ranging from chromatin alterations and pre-initiation complex assembly to promoter clearance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.