ArticleMolecular psychiatry2003
Analysis of reelin as a candidate gene for autism.
Article in Molecular psychiatry, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 128 citations in OpenAlex.
- Association of Allelic Variants of the Reelin Gene with Autistic Spectrum Disorder: A Systematic Review and Meta-Analysis of Candidate Gene Association Studies.International journal of environmental research and public health · 2020Pooled it
- A heterogeneity-based genome search meta-analysis for autism-spectrum disorders.Molecular psychiatry · 2006Pooled it
- Analysis of the RELN gene as a genetic risk factor for autism.Molecular psychiatry · 2005Trial
- Zygosity-Dependent Phenotypic Spectrum ofHuman mutation · 2026Article
- Monoallelic and biallelic mutations in RELN underlie a graded series of neurodevelopmental disorders.Brain : a journal of neurology · 2022Article
- New Strategies for the Treatment of Neuropsychiatric Disorders Based on Reelin Dysfunction.International journal of molecular sciences · 2022Review
- The Pathophysiological Link Between Reelin and Autism: Overview and New Insights.Frontiers in genetics · 2022Review
- Article
- Genetics of structural and functional brain changes in autism spectrum disorder.Translational psychiatry · 2020Review
- TheJournal of clinical medicine · 2019Review
- Autism Spectrum Disorder and miRNA: An Overview of Experimental Models.Brain sciences · 2019Review
- Reelin Signaling Controls the Preference for Social Novelty in Zebrafish.Frontiers in behavioral neuroscience · 2019Article
- The de novo autism spectrum disorder RELN R2290C mutation reduces Reelin secretion and increases protein disulfide isomerase expression.Journal of neurochemistry · 2017Article
- Fundamental Elements in Autism: From Neurogenesis and Neurite Growth to Synaptic Plasticity.Frontiers in cellular neuroscience · 2017Review
- Reelin and Neuropsychiatric Disorders.Frontiers in cellular neuroscience · 2016Review
- RELN Mutations in Autism Spectrum Disorder.Frontiers in cellular neuroscience · 2016Review
- An evo-devo approach to thyroid hormones in cerebral and cerebellar cortical development: etiological implications for autism.Frontiers in endocrinology · 2014Review
- Mapping pathological phenotypes in reelin mutant mice.Frontiers in pediatrics · 2014Article
- Association between the g.296596G > A genetic variant of RELN gene and susceptibility to autism in a Chinese Han population.Genetics and molecular biology · 2013Article
- The involvement of Reelin in neurodevelopmental disorders.Neuropharmacology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
Abstract
Genetic studies indicate that chromosome 7q is likely to contain an autism susceptibility locus (AUTS1). We have followed a positional candidate gene approach to identify relevant gene(s) and report here the analysis of reelin (RELN), a gene located under our peak of linkage. Screening RELN for DNA changes identified novel missense variants absent in a large control group; however, the low frequency of these mutations does not explain the relatively strong linkage results on 7q. Furthermore, analysis of a previously reported triplet repeat polymorphism and intragenic single nucleotide polymorphisms, using the transmission disequilibrium test, provided no evidence for association with autism in IMGSAC and German singleton families. The analysis of RELN suggests that it probably does not play a major role in autism aetiology, although further analysis of several missense mutations is warranted in additional affected individuals.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.