ArticleMolecular psychiatry2003
DNA microarray profiling of developing PS1-deficient mouse brain reveals complex and coregulated expression changes.
Article in Molecular psychiatry, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Role of Imaging Genetics in Alzheimer's Disease: A Systematic Review and Current Update.CNS & neurological disorders drug targets · 2024Pooled it
- Differentiated Embryonic Neurospheres from Familial Alzheimer's Disease Model Show Innate Immune and Glial Cell Responses.Stem cell reviews and reports · 2023Article
- A Life at the Interface: The 2017 Hower Award Lecture.Pediatric neurology · 2018Article
- Aiming at neuroblastoma and hitting other worthy targets.Journal of child neurology · 2013Review
- Chopper is prodeath regardless of the effect of p75ICD on sensitivity to oxidative stress.Oxidative medicine and cellular longevity · 2011Article
- Transcriptome of embryonic and neonatal mouse cortex by high-throughput RNA sequencing.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Target identification for CNS diseases by transcriptional profiling.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2009Review
- Molecular signatures of neurodegeneration in the cortex of PS1/PS2 double knockout mice.Molecular neurodegeneration · 2008Article
- Aging stem cells, latexin, and longevity.Experimental cell research · 2008Review
- Structure of human carboxypeptidase A4 with its endogenous protein inhibitor, latexin.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Presenilin-1-dependent transcriptome changes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Blood-brain barrier genomics, proteomics, and new transporter discovery.NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics · 2005Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Presenilin 1 (PS1) plays a critical role in the nervous system development and PS1 mutations have been associated with familial Alzheimer's disease. PS1-deficient mice exhibit alterations in neural and vascular development and die in late embryogenesis. The present study was aimed at uncovering transcript networks that depend on intact PS1 function in the developing brain. To achieve this, we analyzed the brains of PS1-deficient and control animals at embryonic ages E12.5 and E14.5 using MG_U74Av2 oligonucleotide microarrays by Affymetrix. Based on the microarray data, overall molecular brain development appeared to be comparable between the E12.5 and E14.5 PS1-deficient and control embryos. However, in brains of PS1-deficient mice, we observed significant differences in the expression of genes encoding molecules that are associated with neural differentiation, extracellular matrix, vascular development, Notch-related signaling and lipid metabolism. Many of the expression differences between wild-type and PS1-deficient animals were present at both E12.5 and E14.5, whereas other transcript alterations were characteristic of only one developmental stage. The results suggest that the role of PS1 in development includes influences on a highly co-regulated transcript network; some of the genes participating in this expression network may contribute to the pathophysiology of Alzheimer's disease.
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Registered trials
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