ArticleThe Journal of physiology2003
Glycine receptors and glycinergic synaptic input at the axon terminals of mammalian retinal rod bipolar cells.
Article in The Journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 1 citations in OpenAlex.
- Non-canonical type 1 cannabinoid receptor signaling regulates night visual processing in the inner rat retina.iScience · 2024Article
- Different types of retinal inhibition have distinct neurotransmitter release properties.Journal of neurophysiology · 2015Article
- Expression of CaV3.2 T-type Ca²⁺ channels in a subpopulation of retinal type-3 cone bipolar cells.Neuroscience · 2012Article
- Selective glycine receptor α2 subunit control of crossover inhibition between the on and off retinal pathways.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- GABA(B) receptor feedback regulation of bipolar cell transmitter release.The Journal of physiology · 2010Article
- Mechanisms underlying lateral GABAergic feedback onto rod bipolar cells in rat retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Glycinergic input of widefield, displaced amacrine cells of the mouse retina.The Journal of physiology · 2009Article
- Properties of glycine receptors underlying synaptic currents in presynaptic axon terminals of rod bipolar cells in the rat retina.The Journal of physiology · 2009Article
- Ectopic expression of multiple microbial rhodopsins restores ON and OFF light responses in retinas with photoreceptor degeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Passive membrane properties and electrotonic signal processing in retinal rod bipolar cells.The Journal of physiology · 2009Article
- Comparisons of structural and functional abnormalities in mouse b-wave mutants.The Journal of physiology · 2008Review
- Synaptic regulation of the light-dependent oscillatory currents in starburst amacrine cells of the mouse retina.Journal of neurophysiology · 2008Article
- Diverse mechanisms underlie glycinergic feedback transmission onto rod bipolar cells in rat retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Development of presynaptic inhibition onto retinal bipolar cell axon terminals is subclass-specific.Journal of neurophysiology · 2008Article
- Spontaneous IPSCs and glycine receptors with slow kinetics in wide-field amacrine cells in the mature rat retina.The Journal of physiology · 2007Article
- Functional properties of spontaneous IPSCs and glycine receptors in rod amacrine (AII) cells in the rat retina.The Journal of physiology · 2006Article
- Receptor and transmitter release properties set the time course of retinal inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Ectopic expression of a microbial-type rhodopsin restores visual responses in mice with photoreceptor degeneration.Neuron · 2006Article
- GABA(A), GABA(C) and glycine receptor-mediated inhibition differentially affects light-evoked signalling from mouse retinal rod bipolar cells.The Journal of physiology · 2006Article
- Differential expression of three T-type calcium channels in retinal bipolar cells in rats.Visual neuroscienceArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
We investigated the properties of glycine receptors and glycinergic synaptic inputs at the axon terminals of rod bipolar cells (RBCs) in rats by patch-clamp recording. Glycine currents recorded from isolated axon terminals were larger than those from isolated somata/dendrites; this was confirmed by puffing glycine onto these two regions in retinal slices. The current density at terminal endings was more than one order of magnitude higher than the density at somatic/dendritic regions. Glycine currents from isolated terminals and isolated somata/dendrites showed similar sensitivity to picrotoxinin blockade. Single-channel opening recorded from isolated terminals and somata/dendrites displayed a similar main-state conductance of ~46 pS. Application of glycine effectively suppressed depolarization-evoked increases in intracellular Ca2+ at the terminals. In the presence of GABAA and GABAC antagonists, strychnine-sensitive chloride currents were evoked in RBCs in retinal slices by puffing kainate onto the inner plexiform layer. No such currents were observed if the recorded RBCs did not retain axon terminals or if Ca2+ was replaced by Co2+ in the extracellular solution. The currents displayed discrete miniature-like events, which were partially blocked by tetrodotoxin. Consistent with early studies in the rabbit and mouse, this study demonstrates that glycine receptors are highly concentrated at the axon terminals of rat RBCs. The pharmacological and physiological properties of glycine receptors located in the axon terminal and somatic/dendritic regions, however, appear to be the same. This study provides evidence for the existence of functional glycinergic synaptic input at the axon terminals of RBCs, suggesting that glycine receptors may play a role in modulating bipolar cell synaptic transmission.
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