ArticleAmerican journal of human genetics2003
Haplotypes in the dystrophin DNA segment point to a mosaic origin of modern human diversity.
Article in American journal of human genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
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- Haplotype-Based Approach Represents Locus Specificity in the Genomic Diversification Process in Humans (Genes · 2024Review
- Signatures of human European Palaeolithic expansion shown by resequencing of non-recombining X-chromosome segments.European journal of human genetics : EJHG · 2017Article
- Evidence for archaic adaptive introgression in humans.Nature reviews. Genetics · 2015Review
- Human Dispersal Out of Africa: A Lasting Debate.Evolutionary bioinformatics online · 2015Review
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- A haplotype at STAT2 Introgressed from neanderthals and serves as a candidate of positive selection in Papua New Guinea.American journal of human genetics · 2012Article
- Current genetic methodologies in the identification of disaster victims and in forensic analysis.Journal of applied genetics · 2012Review
- The origin of Eastern European Jews revealed by autosomal, sex chromosomal and mtDNA polymorphisms.Biology direct · 2010Article
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- Female-to-male breeding ratio in modern humans-an analysis based on historical recombinations.American journal of human genetics · 2010Article
- Analysis of the Fragile X Trinucleotide Repeat in Basques: Association of Premutation and Intermediate Sizes, Anchoring AGGs and Linked Microsatellites with Unstable Alleles.Current genomics · 2008Article
- Fraction of informative recombinations: a heuristic approach to analyze recombination rates.Genetics · 2008Article
- Article
- Tracing genetic history of modern humans using X-chromosome lineages.Human genetics · 2007Article
- Genetic variation and population structure in native Americans.PLoS genetics · 2007Article
- Admixture dynamics in Hispanics: a shift in the nuclear genetic ancestry of a South American population isolate.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Contribution of a common single-nucleotide polymorphism to the genetic predisposition for erythropoietic protoporphyria.American journal of human genetics · 2006Article
- The use of racial, ethnic, and ancestral categories in human genetics research.American journal of human genetics · 2005Review
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13 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Although Africa has played a central role in human evolutionary history, certain studies have suggested that not all contemporary human genetic diversity is of recent African origin. We investigated 35 simple polymorphic sites and one T(n) microsatellite in an 8-kb segment of the dystrophin gene. We found 86 haplotypes in 1,343 chromosomes from around the world. Although a classical out-of-Africa topology was observed in trees based on the variant frequencies, the tree of haplotype sequences reveals three lineages accounting for present-day diversity. The proportion of new recombinants and the diversity of the T(n) microsatellite were used to estimate the age of haplotype lineages and the time of colonization events. The lineage that underwent the great expansion originated in Africa prior to the Upper Paleolithic (27,000-56,000 years ago). A second group, of structurally distinct haplotypes that occupy a central position on the tree, has never left Africa. The third lineage is represented by the haplotype that lies closest to the root, is virtually absent in Africa, and appears older than the recent out-of-Africa expansion. We propose that this lineage could have left Africa before the expansion (as early as 160,000 years ago) and admixed, outside of Africa, with the expanding lineage. Contemporary human diversity, although dominated by the recently expanded African lineage, thus represents a mosaic of different contributions.
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