ArticleAmerican journal of human genetics2003
Localization of a gene for migraine without aura to chromosome 4q21.
Article in American journal of human genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.
- Meta-analysis of genome-wide association for migraine in six population-based European cohorts.European journal of human genetics : EJHG · 2011Pooled it
- Migraine with and without aura-two distinct entities? A narrative review.The journal of headache and pain · 2025Review
- The Dawn and Advancement of the Knowledge of the Genetics of Migraine.Journal of clinical medicine · 2024Review
- Migraine genetics: current findings and future lines of research.Neurogenetics · 2015Article
- Studies on the pathophysiology and genetic basis of migraine.Current genomics · 2013Article
- Heritability and genome-wide linkage analysis of migraine in the genetic isolate of Norfolk Island.Gene · 2012Article
- Genetics of migraine in the age of genome-wide association studies.The journal of headache and pain · 2012Review
- Identification of molecular genetic factors that influence migraine.Molecular genetics and genomics : MGG · 2011Review
- Sodium channelopathies and pain.Pflugers Archiv : European journal of physiology · 2010Review
- A visual migraine aura locus maps to 9q21-q22.Neurology · 2010Article
- A genome-wide linkage study of bipolar disorder and co-morbid migraine: replication of migraine linkage on chromosome 4q24, and suggestion of an overlapping susceptibility region for both disorders on chromosome 20p11.Journal of affective disorders · 2010Article
- Bayesian latent trait modeling of migraine symptom data.Human genetics · 2009Article
- Molecular genetics of migraine.Human genetics · 2009Review
- Familial hemiplegic migraine: linkage to chromosome 14q32 in a Spanish kindred.Neurogenetics · 2009Article
- Linkage and heritability analysis of migraine symptom groupings: a comparison of three different clustering methods on twin data.Human genetics · 2009Article
- Investigating the genetic role of aquaporin4 gene in migraine.The journal of headache and pain · 2009Article
- Migraine: a genetic disease?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2008Review
- Consistently replicating locus linked to migraine on 10q22-q23.American journal of human genetics · 2008Article
- Genome-wide scan and fine-mapping linkage study of androgenetic alopecia reveals a locus on chromosome 3q26.American journal of human genetics · 2008Article
- Molecular mechanisms of migraine?Journal of neurology · 2007Review
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Migraine is a common form of headache and has a significant genetic component. Here, we report linkage results from a study in Iceland of migraine without aura (MO). The study group comprised patients with migraine recruited by neurologists and from the registry of the Icelandic Migraine Society, as well as through the use of a questionnaire sent to a random sample of 20,000 Icelanders. Migraine diagnoses were made and confirmed using diagnostic criteria established by the International Headache Society. A genome-wide scan with multipoint allele-sharing methods was performed on 289 patients suffering from MO. Linkage was observed to a locus on chromosome 4q21 (LOD=2.05; P=.001). The locus reported here overlaps a locus (MGR1) reported elsewhere for patients with migraine with aura (MA) in the Finnish population. This replication of the MGR1 locus in families with MO indicates that the gene we have mapped may contribute to both MA and MO. Further analysis indicates that the linkage evidence improves for affected females and, especially, with a slightly relaxed definition of MO (LOD=4.08; P=7.2 x 10(-6)).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.