Evidence map›Paper›PMID 14513359›Full record

ArticleHuman genetics2003

No evidence for DUP25 in patients with panic disorder using a quantitative real-time PCR approach.

Johannes Schumacher, Andreas C J Otte, Tim Becker, Yuli Sun, Thomas F Wienker, Brunhilde Wirth, Petra Franke, Rami Abou Jamra, Peter Propping, Jürgen Deckert and 2 more

Abstract read
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In one paragraph

Article in Human genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Genomic structural variation in affective, anxiety, and stress-related disorders.Journal of neural transmission (Vienna, Austria : 1996) · 2015
    Review
  2. Review
  3. Review
  4. Genetics of anxiety disorders.Current psychiatry reports · 2004
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Johannes SchumacherInstitute of Human Genetics, University of Bonn, Wilhelmstrasse 31, 53111 Bonn, Germany. johannes.schumacher@uni-bonn.de
Andreas C J Otte
Tim Becker
Yuli Sun
Thomas F Wienker
Brunhilde Wirth
Petra Franke
Rami Abou Jamra
Peter Propping
Jürgen Deckert
Markus M Nöthen
Sven Cichon

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A duplication of chromosome 15q24-q26 (DUP25) has been reported to be associated with anxiety disorders. We tested for the presence of DUP25 in a sample of 50 patients with panic disorder and 50 controls using a quantitative real-time PCR approach. Contrary to the original finding, our results were compatible with the absence of DUP25, and no significant difference could be detected between patients and controls ( P=1.0). Thus, our study does not support the hypothesis of an involvement of DUP25 in panic disorder.

Indexed as

Gene DuplicationChromosome MappingChromosomes, Human, Pair 11Chromosomes, Human, Pair 13Chromosomes, Human, Pair 15Cyclic AMP Response Element-Binding ProteinHumansNerve Tissue ProteinsPanic DisorderPolymerase Chain ReactionRNA-Binding ProteinsSMN Complex ProteinsCyclic AMP Response Element-Binding ProteinNerve Tissue ProteinsRNA-Binding ProteinsSMN Complex Proteins

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.