ArticleJournal of virology2003
Human cytomegalovirus inhibits differentiation of monocytes into dendritic cells with the consequence of depressed immunological functions.
Article in Journal of virology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 64 citations in OpenAlex.
- Role of the Virome in Vaccine-Induced Immunization.Vaccines · 2025Review
- Modulation of Monocyte Effector Functions and Gene Expression by Human Cytomegalovirus Infection.Viruses · 2024Review
- The Pentamer glycoprotein complex inhibits viral Immediate Early transcription during Human Cytomegalovirus infections.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Equine Arteritis Virus in Monocytic Cells Suppresses Differentiation and Function of Dendritic Cells.Viruses · 2023Article
- Tuning the Orchestra: HCMV vs. Innate Immunity.Frontiers in microbiology · 2020Review
- The Differentiation of Human Cytomegalovirus Infected-Monocytes Is Required for Viral Replication.Frontiers in cellular and infection microbiology · 2020Review
- Role of cytomegalovirus on the maturation and function of monocyte derived dendritic cells of liver transplant patients.World journal of transplantation · 2016Article
- The Microbiome, Systemic Immune Function, and Allotransplantation.Clinical microbiology reviews · 2016Review
- Human cytomegalovirus modulates monocyte-mediated innate immune responses during short-term experimental latency in vitro.Journal of virology · 2014Article
- Impaired direct priming of CD8 T cells by donor-derived cytomegalovirus following kidney transplantation.Journal of the American Society of Nephrology : JASN · 2013Article
- Diverse immune evasion strategies by human cytomegalovirus.Immunologic research · 2012Review
- Dendritic cell biology in human cytomegalovirus infection and the clinical consequences for host immunity and pathology.Virulence · 2012Review
- Interplay between human cytomegalovirus and intrinsic/innate host responses: a complex bidirectional relationship.Mediators of inflammation · 2012Review
- Toxoplasma gondii infection induces suppression in a mouse model of allergic airway inflammation.PloS one · 2012Article
- The mouse cytomegalovirus glycoprotein m155 inhibits CD40 expression and restricts CD4 T cell responses.Journal of virology · 2011Article
- Cytomegalovirus-induced immunopathology and its clinical consequences.Herpesviridae · 2011Article
- Exogenous control of the expression of Group I CD1 molecules competent for presentation of microbial nonpeptide antigens to human T lymphocytes.Clinical & developmental immunology · 2011Review
- Inhibition of CD1 antigen presentation by human cytomegalovirus.Journal of virology · 2008Article
- Immunomodulatory properties of a viral homolog of human interleukin-10 expressed by human cytomegalovirus during the latent phase of infection.Journal of virology · 2008Article
- Herpesvirus interference with major histocompatibility complex class II-restricted T-cell activation.Journal of virology · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human cytomegalovirus (HCMV) infections in immunocompromised patients are associated with impaired immunological functions. Blood monocytes, which can differentiate into dendritic cells upon cytokine stimulation, play a central role in adequate immune reactivity and are believed to carry latent HCMV. We demonstrate here that HCMV infection of monocytes results in a block in the cytokine-induced differentiation of monocytes into functionally active CD1a-positive dendritic cells, which exhibited severely depressed immunological functions in vitro. The HCMV-infected cells exhibited a significantly reduced ability to endocytose fluorescein isothiocyanate-labeled dextran particles as well as a more than 90% reduced ability to migrate in response to the chemoattractant factors RANTES, MIP-1alpha, and MIP-3beta. Interestingly, HCMV-infected cells expressed high levels of the costimulatory molecule CD86, in contrast to the low levels of expression that was observed on uninfected monocytes and uninfected immature dendritic cells. Furthermore, HCMV-infected CD1a-negative cells were unable to induce a T-cell response. Thus, these observations suggest that HCMV infection of monocytes in vitro blocks cytokine-induced dendritic cell differentiation, and since dendritic cells play a central role in initiating immune responses, these findings suggest a powerful tactic to avoid immune recognition and to blunt the immune response at early phases of infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.