ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2003
Epigenetic asymmetry in the mammalian zygote and early embryo: relationship to lineage commitment?
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Neurotrophin-4 promotes the specification of trophectoderm lineage after parthenogenetic activation and enhances porcine early embryonic development.Frontiers in cell and developmental biology · 2023Article
- Epigenetic Reprogramming During Somatic Cell Nuclear Transfer: Recent Progress and Future Directions.Frontiers in genetics · 2020Review
- On Mammalian Totipotency: What Is the Molecular Underpinning for the Totipotency of Zygote?Stem cells and development · 2019Review
- Substantial Epigenetic Variation Causing Flower Color Chimerism in the Ornamental TreeInternational journal of molecular sciences · 2018Article
- Factors and molecules that could impact cell differentiation in the embryo generated by nuclear transfer.Organogenesis · 2017Review
- Transcriptional Regulation of the First Cell Fate Decision.Journal of developmental biology & regenerative medicine · 2017Article
- Biologic relativity: Who is the observer and what is observed?Progress in biophysics and molecular biology · 2016Review
- Epigenetic disruptions of histone signatures for the trophectoderm and inner cell mass in mouse parthenogenetic embryos.Stem cells and development · 2015Article
- Origin of cellular asymmetries in the pre-implantation mouse embryo: a hypothesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Article
- The maternal to zygotic transition in mammals.Molecular aspects of medicine · 2013Review
- Neocortical development as an evolutionary platform for intragenomic conflict.Frontiers in neuroanatomy · 2013Article
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- Hypomethylation of functional retrotransposon-derived genes in the human placenta.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Article
- Efficient production and cellular characterization of sheep androgenetic embryos.Cellular reprogramming · 2011Article
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- MLL2 is required in oocytes for bulk histone 3 lysine 4 trimethylation and transcriptional silencing.PLoS biology · 2010Article
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- Localization of DNA methyltransferase-1 during oocyte differentiation, in vitro maturation and early embryonic development in cow.European journal of histochemistry : EJH · 2009Article
- Epigenetic responses to environmental change and their evolutionary implications.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2009Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epigenetic asymmetry between parental genomes and embryonic lineages exists at the earliest stages of mammalian development. The maternal genome in the zygote is highly methylated in both its DNA and its histones and most imprinted genes have maternal germline methylation imprints. The paternal genome is rapidly remodelled with protamine removal, addition of acetylated histones, and rapid demethylation of DNA before replication. A minority of imprinted genes have paternal germline methylation imprints. Methylation and chromatin reprogramming continues during cleavage divisions, but at the blastocyst stage lineage commitment to inner cell mass (ICM) or trophectoderm (TE) fate is accompanied by a dramatic increase in DNA and histone methylation, predominantly in the ICM. This may set up major epigenetic differences between embryonic and extraembryonic tissues, including in X-chromosome inactivation and perhaps imprinting. Maintaining epigenetic asymmetry appears important for development as asymmetry is lost in cloned embryos, most of which have developmental defects, and in particular an imbalance between extraembryonic and embryonic tissue development.
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