ArticleEuropean journal of clinical pharmacology2003
Statin compliance in the Umbrian population.
Article in European journal of clinical pharmacology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Prevalence of statin intolerance: a meta-analysis.European heart journal · 2022 · on this mapPooled it
- Predictors of nonadherence to statins: a systematic review and meta-analysis.The Annals of pharmacotherapy · 2010Pooled it
- Validity of cerebrovascular ICD-9-CM codes in healthcare administrative databases. The Umbria Data-Value Project.PloS one · 2020Article
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- Adherence with statins in a real-life setting is better when associated cardiovascular risk factors increase: a cohort study.BMC cardiovascular disorders · 2011Article
- The significance of compliance and persistence in the treatment of diabetes, hypertension and dyslipidaemia: a review.International journal of clinical practice · 2008Review
- Adherence to chronic cardiovascular therapies: persistence over the years and dose coverage.British journal of clinical pharmacology · 2007Article
- Improvement of cardiovascular risk profile in an elderly population of low social level: the ICON (Improving Cardiovascular risk profile in Older Neapolitans) study.Journal of human hypertension · 2007Article
- Underuse of lipid-lowering drugs and factors associated with poor adherence: a real practice analysis in Italy.European journal of clinical pharmacology · 2005Article
- Predictors of first-year statin medication discontinuation: A cohort study.Journal of clinical lipidologyArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo explore compliance with statin treatment over a period of 4.5 years follow-up in an Italian population and to investigate the degree of persistence and continuity in subjects with cardiovascular diseases.
methodsPharmaceutical, medical and demographic data were retrieved from the database of Umbria Regional Government's Epidemiology Department. Statin users were stratified in different cohorts according to drug use, aspirin use and hospital admission for cardiovascular diseases. Compliance was considered in terms of persistence and continuity. Persistence was defined as discontinued if the delay between the end of the first period of treatment and the prescription renewal exceeded 30 days. Continuity was defined as consecutive annual renewal of prescription.
resultsStatin users (n=39,222) were identified. The median persistence on statin treatment was 5.3 months. Only 12.8% subjects were found to be persistent, while 49.6% renewed their prescription for consecutive years. The cohorts of aspirin use and major cardiovascular events were predictive of good compliance. In these cohorts subjects under 45 years showed the best rate of persistence and continuity.
conclusionThe study reveals low compliance among subjects who presumably receive prescriptions for primary prevention. We consider it important for these groups of patients to receive greater attention and better information.
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