ArticleOncogene2003
Hyperexpression of locus C genes in the HOX network is strongly associated in vivo with human bladder transitional cell carcinomas.
Article in Oncogene, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Role of androgen receptor expression in non-muscle-invasive bladder cancer: a systematic review and meta-analysis.Histology and histopathology · 2020Pooled it
- Homeobox Gene Expression Dysregulation as Potential Diagnostic and Prognostic Biomarkers in Bladder Cancer.Diagnostics (Basel, Switzerland) · 2023Review
- A transcriptional network of cell cycle dysregulation in noninvasive papillary urothelial carcinoma.Scientific reports · 2022Article
- The involvement of homeobox-C 4 in predicting prognosis and unraveling immune landscape across multiple cancersFrontiers in genetics · 2022Article
- Knockdown of lncRNAEvidence-based complementary and alternative medicine : eCAM · 2022Article
- The expression ofAnnals of translational medicine · 2022Article
- Long Non-coding RNA HOXA11-AS Facilitates Proliferation of Lung Adenocarcinoma CellsFrontiers in genetics · 2022Article
- Widespread overexpression from the four DNA hypermethylated HOX clusters in aggressive (IDHwt) glioma is associated with H3K27me3 depletion and alternative promoter usage.Molecular oncology · 2021Article
- LncRNA HOTAIR Promotes Proliferation of Malignant Melanoma Cells through NF-ϰB Pathway.Iranian journal of public health · 2020Article
- HOX gene cluster (de)regulation in brain: from neurodevelopment to malignant glial tumours.Cellular and molecular life sciences : CMLS · 2020Review
- HOXC10 upregulation confers resistance to chemoradiotherapy in ESCC tumor cells and predicts poor prognosis.Oncogene · 2020Article
- Expression Profile and Prognostic Values ofFrontiers in oncology · 2020Article
- Oncogenic and tumor suppressor function of MEIS and associated factors.Turkish journal of biology = Turk biyoloji dergisi · 2020Article
- HOXA11 antisense long noncoding RNA (HOXA11-AS): A promising lncRNA in human cancers.Cancer medicine · 2018Review
- Long Non-coding RNACancer research and treatment · 2017Article
- HOXC6 Overexpression Is Associated With Ki-67 Expression and Poor Survival in NPC Patients.Journal of Cancer · 2017Article
- Effect of overexpression ofOncology letters · 2016Article
- Transcriptional dynamics of homeobox C11 gene in water buffalo bubalus bubalis.DNA and cell biology · 2015Article
- The long noncoding RNA HOTAIR has tissue and cell type-dependent effects on HOX gene expression and phenotype of urothelial cancer cells.Molecular cancer · 2015Article
- HOXB9 promotes epithelial-to-mesenchymal transition via transforming growth factor-β1 pathway in hepatocellular carcinoma cells.Clinical and experimental medicine · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bladder carcinogenesis remains unclear despite the identification of chemical, environmental and genetic factors. It has recently been reported that the chromosomal region 12q13-q15, containing crucial cancer genes such as MDM2, CDK4 and GLI, is amplified in bladder cancer. In the same region are also located the genes of the locus HOX C, flanked by keratin genes whose protein product may be a prognostic marker of bladder cancer. The HOX genes constitute a network of transcription factors controlling embryonal development and play an important role in crucial adult eukaryotic cell functions. The molecular organization of this 39-gene network is unique in the genome and probably acts by regulating phenotypical cell identity. We have analysed the expression of the whole HOX gene network in pairs of normal-tumour bladder and in tumoral biopsies. Comparison between normal urothelium and bladder tumour has identified dramatic variations of expression in a block of three genes (HOX C4, HOX C5 and HOX C6) localized in the HOX C locus on the chromosome 12q13 and in the paralogous group 11 HOX genes, involved during normal development in the formation of the urogenital system. These data suggest a key involvement of the HOX gene network, and especially the locus C, in bladder cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.