ArticleOncogene2003
Cdx1 inhibits the proliferation of human colon cancer cells by reducing cyclin D1 gene expression.
Article in Oncogene, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 47 citations in OpenAlex.
- The inhibition of enterocyte proliferation by lithocholic acid exacerbates necrotizing enterocolitis through downregulating the Wnt/β-catenin signalling pathway.Cell proliferation · 2022Article
- Improved detection of tumor suppressor events in single-cell RNA-Seq data.NPJ genomic medicine · 2020Article
- Association analysis using somatic mutations.PLoS genetics · 2018Article
- Article
- Application of unique sequence index (USI) barcode to gene expression profiling in gastric adenocarcinoma.Journal of cell communication and signaling · 2017Article
- Impact of homeobox genes in gastrointestinal cancer.World journal of gastroenterology · 2016Review
- Computational Identification of Key Regulators in Two Different Colorectal Cancer Cell Lines.Frontiers in genetics · 2016Article
- mRNA expression profiles in circulating tumor cells of metastatic colorectal cancer patients.Molecular oncology · 2015Article
- MicroRNA-296-5p increases proliferation in gastric cancer through repression of Caudal-related homeobox 1.Oncogene · 2014Article
- Methylation-dependent activation of CDX1 through NF-κB: a link from inflammation to intestinal metaplasia in the human stomach.The American journal of pathology · 2012Article
- Intestine-specific transcription factor Cdx2 induces E-cadherin function by enhancing the trafficking of E-cadherin to the cell membrane.American journal of physiology. Gastrointestinal and liver physiology · 2010Article
- The intestine-specific transcription factor Cdx2 inhibits beta-catenin/TCF transcriptional activity by disrupting the beta-catenin-TCF protein complex.Carcinogenesis · 2010Article
- Cdx genes, inflammation, and the pathogenesis of intestinal metaplasia.Progress in molecular biology and translational science · 2010Review
- Induction of intestinalization in human esophageal keratinocytes is a multistep process.Carcinogenesis · 2009Article
- An age-and-cyclin-structured cell population model for healthy and tumoral tissues.Journal of mathematical biology · 2008Article
- The homeodomain transcription factor Cdx1 does not behave as an oncogene in normal mouse intestine.Neoplasia (New York, N.Y.) · 2008Article
- The anti-tumour agent, cisplatin, and its clinically ineffective isomer, transplatin, produce unique gene expression profiles in human cells.Cancer informatics · 2008Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The transcription factor Cdx1 regulates intestine-specific gene expression and enterocyte differentiation. It has been hypothesized to play a role in regulating intestinal cell proliferation; however, the mechanism for this effect remains elusive. In a prior study, we demonstrated that Cdx1 expression reduced the proliferation of a nontransformed intestinal cell line. This study tests the hypothesis that Cdx1 expression inhibits colon cancer cell proliferation by reducing cyclin D1 gene expression. Cdx1 expression markedly reduced cancer cell proliferation and DNA synthesis and induced an accumulation of cells in G0/G1. A transcriptionally inactive Cdx1 mutant could not elicit this effect, suggesting that it required Cdx1 transcriptional activity. Cdx1 expression increased the hypophosphorylation of the retinoblastoma (pRb) and p130 proteins. Reductions in G1 cyclin-dependant kinase (cdk) activity accompanied this effect. Cyclin D1 mRNA and protein levels were diminished by Cdx1 expression. Restoration of cyclin D1 expression reversed the G0/G1 block and induced pRb hyperphosphorylation. Lastly, Cdx1 expression did not alter cyclin D1 mRNA stability but did reduce cyclin D1 promoter activity, suggesting that Cdx1 acts to diminish cyclin D1 gene transcription. We conclude that Cdx1 reduces the proliferation of human colon cancer cells by reducing cyclin D1 gene transcription.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.