ArticleThe Plant cell2003
The Arabidopsis anaphase-promoting complex or cyclosome: molecular and genetic characterization of the APC2 subunit.
Article in The Plant cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 130 citations in OpenAlex.
- Molecular characterization of capulet2 reveals the importance of ANAPHASE PROMOTING COMPLEX 6 maternal expression in endosperm development.Plant physiology · 2026Article
- Dissecting the genetic architecture of flag leaf morphology in Sichuan Wheat Germplasm using genome-wide association study.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Modulating the activity of the APC/C regulator SISAMBA improves the sugar and antioxidant content of tomato fruits.Plant biotechnology journal · 2025Article
- Regulation of cell cycle in plant gametes: when is the right time to divide?Development (Cambridge, England) · 2025Review
- Control of division in Chlamydomonas by cyclin B/CDKB1 and the anaphase-promoting complex.PLoS genetics · 2022Article
- The role of APC/C in cell cycle dynamics, growth and development in cereal crops.Frontiers in plant science · 2022Review
- The Inactivation of ArabidopsisPlants (Basel, Switzerland) · 2021Article
- Connections between the Cell Cycle and the DNA Damage Response in Plants.International journal of molecular sciences · 2021Review
- The Role of Anaphase-Promoting Complex/Cyclosome (APC/C) in Plant Reproduction.Frontiers in plant science · 2021Review
- The Anaphase Promoting Complex/Cyclosome Subunit 11 and Its Role in Organ Size and Plant Development.Frontiers in plant science · 2021Article
- ABAP1 Plays a Role in the Differentiation of Male and Female Gametes inFrontiers in plant science · 2021Article
- Editor Profile: Pascal Genschik.The Plant cell · 2020Article
- Genome-Wide Association Analysis Identifies Candidate Genes Regulating Seed Number Per Silique inPlants (Basel, Switzerland) · 2020Article
- The Arabidopsis anaphase-promoting complex/cyclosome subunit 8 is required for male meiosis.The New phytologist · 2019Article
- Anaphase-promoting complex/cyclosome regulates RdDM activity by degrading DMS3 inProceedings of the National Academy of Sciences of the United States of America · 2019Article
- RNA-seq Analysis Reveals Gene Expression Profiling of Female Fertile and Sterile Ovules ofInternational journal of molecular sciences · 2018Article
- 3D Reconstruction of Lipid Droplets in the Seed of Brassica napus.Scientific reports · 2018Article
- Interregulation of CDKA/CDK1 and the Plant-Specific Cyclin-Dependent Kinase CDKB in Control of the Chlamydomonas Cell Cycle.The Plant cell · 2018Article
- E3 Ubiquitin Ligases: Ubiquitous Actors in Plant Development and Abiotic Stress Responses.Plant & cell physiology · 2017Review
- GmILPA1, Encoding an APC8-like Protein, Controls Leaf Petiole Angle in Soybean.Plant physiology · 2017Article
Corrections and comments
- Erratum issuedCORRECTION.2019
Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In yeast and animals, the anaphase-promoting complex or cyclosome (APC/C) is an essential ubiquitin protein ligase that regulates mitotic progression and exit by controlling the stability of cell cycle regulatory proteins, such as securin and the mitotic cyclins. In plants, the function, regulation, and substrates of the APC/C are poorly understood. To gain more insight into the roles of the plant APC/C, we characterized at the molecular level one of its subunits, APC2, which is encoded by a single-copy gene in Arabidopsis. We show that the Arabidopsis gene is able to partially complement a budding yeast apc2 ts mutant. By yeast two-hybrid assays, we demonstrate an interaction of APC2 with two other APC/C subunits: APC11 and APC8/CDC23. A reverse-genetic approach identified Arabidopsis plants carrying T-DNA insertions in the APC2 gene. apc2 null mutants are impaired in female megagametogenesis and accumulate a cyclin-beta-glucuronidase reporter protein but do not display metaphase arrest, as observed in other systems. The APC2 gene is expressed in various plant organs and does not seem to be cell cycle regulated. Finally, we report intriguing differences in APC2 protein subcellular localization compared with that in other systems. Our observations support a conserved function of the APC/C in plants but a different mode of regulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.