ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Postsynaptic protein kinase A reduces neuronal excitability in response to increased synaptic excitation in the Drosophila CNS.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 47 citations in OpenAlex.
- Conflicting adaptations in an inhibitory feedback circuit.The Journal of physiology · 2026Article
- Article
- Neural mechanisms to exploit positional geometry for collision avoidance.Current biology : CB · 2022Article
- Homeostatic Regulation of Motoneuron Properties in Development.Advances in neurobiology · 2022Review
- Vesicular neurotransmitter transporters in Drosophila melanogaster.Biochimica et biophysica acta. Biomembranes · 2020Review
- Article
- Low Levels of Pyrethroid Resistance in Hybrid Offspring of a Highly Resistant and a More Susceptible Mosquito Strain.Journal of insect science (Online) · 2020Article
- Pumilio Regulates Sleep Homeostasis in Response to Chronic Sleep Deprivation inFrontiers in neuroscience · 2020Article
- Homeostatic plasticity in neural development.Neural development · 2018Review
- Inappropriate Neural Activity during a Sensitive Period in Embryogenesis Results in Persistent Seizure-like Behavior.Current biology : CB · 2015Article
- Sleep restores behavioral plasticity to Drosophila mutants.Current biology : CB · 2015Article
- Regulation of membrane excitability: a convergence on voltage-gated sodium conductance.Molecular neurobiology · 2015Review
- Pumilio-2 regulates translation of Nav1.6 to mediate homeostasis of membrane excitability.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Activity-dependent alternative splicing increases persistent sodium current and promotes seizure.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Cyclic adenosine monophosphate metabolism in synaptic growth, strength, and precision: neural and behavioral phenotype-specific counterbalancing effects between dnc phosphodiesterase and rut adenylyl cyclase mutations.Journal of neurogenetics · 2012Article
- Opportunities for text mining in the FlyBase genetic literature curation workflow.Database : the journal of biological databases and curation · 2012Article
- Endogenous patterns of activity are required for the maturation of a motor network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Increased persistent Na+ current contributes to seizure in the slamdance bang-sensitive Drosophila mutant.Journal of neurophysiology · 2011Article
- Anterograde Jelly belly ligand to Alk receptor signaling at developing synapses is regulated by Mind the gap.Development (Cambridge, England) · 2010Article
- Alternative splicing in the voltage-gated sodium channel DmNav regulates activation, inactivation, and persistent current.Journal of neurophysiology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Previous work has identified a role for synaptic activity in the development of excitable properties of motoneurons in the Drosophila embryo. In this study the underlying mechanism that enables two such neurons, termed aCC and RP2, to respond to increased exposure to synaptic excitation is characterized. Synaptic excitation is increased in genetic backgrounds that lack either a cAMP-specific phosphodiesterase (EC:3.1.4, dunce) or acetylcholinesterase (EC:3.1.1.7, ace), the enzyme that terminates the endogenous cholinergic excitation of these motoneurons. Analysis of membrane excitability in aCC/RP2, in either background, shows that these neurons have a significantly reduced capability to fire action potentials (APs) in response to injection of depolarizing current. Analysis of underlying voltage-gated currents show that this effect is associated with a marked reduction in magnitude of the voltage-dependent inward Na+ current (INa). Partially blocking INa in these motoneurons, using low concentrations of TTX, demonstrates that a reduction of INa is, by itself, sufficient to reduce membrane excitability. An analysis of firing implicates an increased AP threshold to underlie the reduction in membrane excitability observed because of heightened exposure to synaptic excitation. Genetic or pharmacological manipulations that either elevate cAMP or increase protein kinase A (PKA) activity in wild-type aCC/RP2 mimic both the reductions in membrane excitability and INa. In comparison, increasing cAMP catabolism or inhibition of PKA activity is sufficient to block the induction of these activity-dependent changes. The induced changes in excitability can be rapid, occurring within 5 min of exposure to a membrane-permeable cAMP analog, indicative that threshold can be regulated in these neurons by a post-translational mechanism that is dependent on phosphorylation.
Indexed as
Identifiers
14507965PMC6740429W2151968883What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.