ArticleInvestigative ophthalmology & visual science2003
P2Y(2) receptor agonist INS37217 enhances functional recovery after detachment caused by subretinal injection in normal and rds mice.
Article in Investigative ophthalmology & visual science, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 45 citations in OpenAlex.
- Downregulation of rhodopsin is an effective therapeutic strategy in ameliorating peripherin-2-associated inherited retinal disorders.Nature communications · 2024Article
- Increased ApPurinergic signalling · 2018Article
- Microglia inhibit photoreceptor cell death and regulate immune cell infiltration in response to retinal detachment.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Subretinal delivery of erythropoietin alleviates the N-methyl-N-nitrosourea-induced photoreceptor degeneration and visual functional impairments: an in vivo and ex vivo study.Drug delivery · 2017Article
- Non-viral therapeutic approaches to ocular diseases: An overview and future directions.Journal of controlled release : official journal of the Controlled Release Society · 2015Review
- Trans-Corneal Subretinal Injection in Mice and Its Effect on the Function and Morphology of the Retina.PloS one · 2015Article
- Fibulin 2, a tyrosine O-sulfated protein, is up-regulated following retinal detachment.The Journal of biological chemistry · 2014Article
- Neuroprotective roles of the P2Y(2) receptor.Purinergic signalling · 2012Review
- Direct gene transfer with compacted DNA nanoparticles in retinal pigment epithelial cells: expression, repeat delivery and lack of toxicity.Nanomedicine (London, England) · 2012Article
- The effect of subretinal viscoelastics on the porcine retinal function.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2012Article
- Retinoid receptors trigger neuritogenesis in retinal degenerations.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- Nanoparticle-mediated gene transfer specific to retinal pigment epithelial cells.Biomaterials · 2011Article
- DPOFA, a Cl⁻/HCO₃⁻ exchanger antagonist, stimulates fluid absorption across basolateral surface of the retinal pigment epithelium.BMC ophthalmology · 2011Article
- Functional Expression of P2Y Receptors in WERI-Rb1 Retinoblastoma Cells.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2011Article
- Nanoparticles for retinal gene therapy.Progress in retinal and eye research · 2010Review
- Gene delivery to mitotic and postmitotic photoreceptors via compacted DNA nanoparticles results in improved phenotype in a mouse model of retinitis pigmentosa.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- Ocular delivery of compacted DNA-nanoparticles does not elicit toxicity in the mouse retina.PloS one · 2009Article
- The effects of transient retinal detachment on cavity size and glial and neural remodeling in a mouse model of X-linked retinoschisis.Investigative ophthalmology & visual science · 2009Article
- Involvement of Müller glial cells in epiretinal membrane formation.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2009Review
- Upregulation of Semaphorin 3A and the associated biochemical and cellular events in a rat model of retinal detachment.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo evaluate the effects of INS37217 on the recovery of retinal function after experimental retinal detachment induced by subretinal injection.
methodsSubretinal injections of 1 micro L of fluorescent microbeads, saline, or INS37217 (1-200 micro M) were made by the transvitreal method in normal (C57BL/6) mice and in mice heterozygous for the retinal degeneration slow (rds) gene. Control, mock-injected animals underwent corneal puncture without injection. Histologic and ERG evaluations were made at 0 to 1 and 8 hours, and 1, 3, 7, 10, 14, and 60 days post injection (PI). DNA fragmentation was evaluated by terminal deoxynucleotidyl transferase-mediated uridine 5'-triphosphate-biotin nick end labeling (TUNEL).
resultsA single subretinal injection of saline solution containing fluorescent beads caused a histologically evident retinal detachment and distributed the microbeads to almost all the subretinal space. Spontaneous reattachment occurred within 24 hours after injection and was accompanied by evident retinal folding that appeared largely resolved by 6 days later. Relative to controls, injection of saline resulted in approximately 40% recovery of dark-adapted a-wave amplitude at 24 hours PI and gradually improved to approximately 90% of controls at 2 months PI. Subretinal injection of saline containing INS37217 (10 micro M) significantly increased rod and cone ERG of normal and rds(+/-) mice at 1 and 10 days PI, when compared with injection of saline alone. Additionally, INS37217 reduced the number of TUNEL-positive photoreceptors and the enhanced rate of reattachment.
conclusionsEnhancement of ERG recovery by INS37217 is likely due to reduced retinal folding and cell death associated with detachment. These results support the use of INS37217 to help restore function after therapies that involve subretinal administration of drugs in animal models of retinal diseases.
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