ArticleBiophysical journal2003
Computational modeling of cell adhesion and movement using a continuum-kinetics approach.
Article in Biophysical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Platelet Biorheology and Mechanobiology in Thrombosis and Hemostasis: Perspectives from Multiscale Computation.International journal of molecular sciences · 2024Review
- Past, Present, and Future of Affinity-based Cell Separation Technologies.Acta biomaterialia · 2020Review
- On the transport of particles/cells in high-throughput deterministic lateral displacement devices: Implications for circulating tumor cell separation.Biomicrofluidics · 2019Article
- Computational study of cell adhesion and rolling in flow channel by meshfree method.Computer methods in biomechanics and biomedical engineering · 2017Article
- Deformability-based circulating tumor cell separation with conical-shaped microfilters: Concept, optimization, and design criteria.Biomicrofluidics · 2015Article
- Multi-scale biological and physical modelling of the tumour micro-environment.Drug discovery today. Disease models · 2015Article
- Article
- Parametric control of collision rates and capture rates in geometrically enhanced differential immunocapture (GEDI) microfluidic devices for rare cell capture.Biomedical microdevices · 2014Article
- Coupled Particulate and Continuum Model for Nanoparticle Targeted Delivery.Computers & structures · 2013Article
- Effect of deformability difference between two erythrocytes on their aggregation.Physical biology · 2013Article
- Deformable cell-cell and cell-substrate interactions in semi-infinite domain.Journal of biomechanics · 2013Article
- Multiscale computational models of complex biological systems.Annual review of biomedical engineering · 2013Review
- Leukocyte rolling on P-selectin: a three-dimensional numerical study of the effect of cytoplasmic viscosity.Biophysical journal · 2012Article
- Microelectromechanical system-based diagnostic technology for cervical cancer.Journal of cancer research and clinical oncology · 2011Article
- Direct numerical simulation of single leukocyte deformation in microchannel flow for disease diagnosis.Journal of medical systems · 2011Article
- The influence of topographic microstructures on the initial adhesion of L929 fibroblasts studied by single-cell force spectroscopy.European biophysics journal : EBJ · 2011Article
- Rule-Based Simulation of Multi-Cellular Biological Systems-A Review of Modeling Techniques.Cellular and molecular bioengineering · 2009Article
- Coupled Flow-Structure-Biochemistry Simulations of Dynamic Systems of Blood Cells Using an Adaptive Surface Tracking Method.Journal of fluids and structures · 2009Article
- Effects of erythrocyte deformability and aggregation on the cell free layer and apparent viscosity of microscopic blood flows.Microvascular research · 2009Article
- Modeling cell interactions under flow.Journal of mathematical biology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adhesion of leukocytes to substrate involves the coupling of disparate length and timescales between molecular mechanics and macroscopic transport, and existing models of cell adhesion do not use full cellular information. To address these challenges, a multiscale computational approach for studying the adhesion of a cell on a substrate is developed and assessed. The cellular level model consists of a continuum representation of the field equations and a moving boundary tracking capability to allow the cell to change its shape continuously. At the receptor-ligand level, a bond molecule is mechanically represented by a spring. Communication between the macro/micro- and nanoscale models is facilitated interactively during the computation. The computational model is assessed using an adherent cell, rolling and deforming along the vessel wall under imposed shear flows. Using this approach, we first confirm existing numerical and experimental results. In this study, the intracellular viscosity and interfacial tension are found to directly affect the rolling of a cell. Our results also show that the presence of a nucleus increases the bond lifetime, and decreases the cell rolling velocity. Furthermore, it is found that a cell with a larger diameter rolls faster, and decreases the bond lifetime. This study shows that cell rheological properties have significant effects on the adhesion process contrary to what has been hypothesized in most literature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.