ArticleBiophysical journal2003
The effect of chain length on protein solubilization in polymer-based vesicles (polymersomes).
Article in Biophysical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Bioinspired photocatalytic systems towards compartmentalized artificial photosynthesis.Communications chemistry · 2023Review
- Application of polymersomes in membrane protein study and drug discovery: Progress, strategies, and perspectives.Bioengineering & translational medicine · 2023Review
- Mesenchymal Stem Cell-Derived Exosomes: A Potential Therapeutic Avenue in Knee Osteoarthritis.Cartilage · 2021Article
- Probing and Tuning the Permeability of Polymersomes.ACS central science · 2021Review
- Exosomal therapy-a new frontier in regenerative medicine.Stem cell investigation · 2021Review
- Investigating the Mechanisms of AquaporinZ Reconstitution through Polymeric Vesicle Composition for a Biomimetic Membrane.Polymers · 2020Article
- Biotransporting Biocatalytic Reactors toward Therapeutic Nanofactories.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2018Article
- Durable proteo-hybrid vesicles for the extended functional lifetime of membrane proteins in bionanotechnology.Chemical communications (Cambridge, England) · 2016Article
- Simple surface functionalization of polymersomes using non-antibacterial peptide anchors.Journal of nanobiotechnology · 2016Article
- Reconstitution of the membrane protein OmpF into biomimetic block copolymer-phospholipid hybrid membranes.Beilstein journal of nanotechnology · 2016Article
- The Role of Membrane Fluidization in the Gel-Assisted Formation of Giant Polymersomes.PloS one · 2016Article
- Review
- Recent Progress in Advanced Nanobiological Materials for Energy and Environmental Applications.Materials (Basel, Switzerland) · 2013Review
- High-density reconstitution of functional water channels into vesicular and planar block copolymer membranes.Journal of the American Chemical Society · 2012Article
- Recent trends in the tuning of polymersomes' membrane properties.The European physical journal. E, Soft matter · 2011Review
- Interactions of membrane-active peptides with thick, neutral, nonzwitterionic bilayers.The journal of physical chemistry. B · 2005Article
- Effect of membrane characteristics on phase separation and domain formation in cholesterol-lipid mixtures.Biophysical journal · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using a mean-field analysis we derive a consistent model for the perturbation of a symmetric polymeric bilayer due to the incorporation of transmembrane proteins, as a function of the polymer molecular weight and the protein dimensions. We find that the mechanism for the inhibition of protein incorporation in polymeric bilayers differs from that of their inclusion in polymer-carrying lipid vesicles; in polymersomes, the equilibrium concentration of transmembrane proteins decreases as a function of the thickness mismatch between the protein and the bilayer core, whereas in liposomes the presence of polymer chains affects the protein adsorption kinetics. Despite the increased stiffness of polymer bilayers (when compared to lipid ones), their perturbation decay length and range of protein-protein interaction is found to be relatively long. The energetic penalty due to protein adsorption increases relatively slowly as a function of the polymer chain length due to the self-assembled nature of the polymer bilayer. As a result, we predict that transmembrane proteins may be incorporated in significant numbers even in bilayers where the thickness mismatch is large.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.