ArticleThe American journal of pathology2003
Respiratory reovirus 1/L induction of intraluminal fibrosis, a model of bronchiolitis obliterans organizing pneumonia, is dependent on T lymphocytes.
Article in The American journal of pathology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 59 citations in OpenAlex.
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- IL13 May Play an Important Role in Developing Eosinophilic Chronic Rhinosinusitis and Eosinophilic Otitis Media with Severe Asthma.International journal of molecular sciences · 2021Article
- The contribution of animal models to understanding the role of the immune system in human idiopathic pulmonary fibrosis.Clinical & translational immunology · 2020Article
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- Current Approach to Non-Infectious Pulmonary Complications of Hematopoietic Stem Cell Transplantation.Balkan medical journal · 2018Review
- Organizing pneumonia in mice and men.Journal of translational medicine · 2016Article
- Carnosine markedly ameliorates H9N2 swine influenza virus-induced acute lung injury.The Journal of general virology · 2015Article
- Tocilizumab for refractory organising pneumonia associated with Sjögren's disease.BMJ case reports · 2015Article
- N-acetyl-l-cystine (NAC) protects against H9N2 swine influenza virus-induced acute lung injury.International immunopharmacology · 2014Article
- Reovirus-associated meningoencephalomyelitis in baboons.Veterinary pathology · 2014Article
- Respiratory infection of mice with mammalian reoviruses causes systemic infection with age and strain dependent pneumonia and encephalitis.Virology journal · 2013Article
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- Lung Contusion: A Clinico-Pathological Entity with Unpredictable Clinical Course.Bulletin of emergency and trauma · 2013Review
- Resolution of immune response by recombinant transforming growth factor-beta (rTGF-β) during influenza A virus infection.The Indian journal of medical research · 2012Article
- Histopathological analogies in chronic pulmonary lesions between cattle and humans: basis for an alternative animal model.TheScientificWorldJournal · 2012Review
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- Stem cells in clinical practice: applications and warnings.Journal of experimental & clinical cancer research : CR · 2011Review
- Bronchiolitis obliterans organizing pneumonia in Swine associated with porcine circovirus type 2 infection.Journal of biomedicine & biotechnology · 2011Article
- Acute respiratory distress syndrome induced by H9N2 virus in mice.Archives of virology · 2010Article
- Differential role of the Fas/Fas ligand apoptotic pathway in inflammation and lung fibrosis associated with reovirus 1/L-induced bronchiolitis obliterans organizing pneumonia and acute respiratory distress syndrome.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Bronchiolitis obliterans organizing pneumonia (BOOP) is a clinical syndrome characterized by perivascular/peribronchiolar leukocyte infiltration leading to the development of intraalveolar fibrosis. We have developed an animal model of BOOP where CBA/J mice infected with 1 x 10(6) plaque-forming units (PFU) reovirus 1/L develop follicular bronchiolitis and intraalveolar fibrosis similar to human BOOP. In this report, we demonstrate a role for T cells in the development of intraluminal fibrosis associated with BOOP. Corticosteroid treatment of reovirus 1/L-infected mice both inhibited the development of fibrotic lesions when administered early in the time-course and promoted the resolution of fibrotic lesions when corticosteroid administration was delayed. Further, the depletion of either CD4(+) or CD8(+) T cells before reovirus 1/L infection also inhibited fibrotic lesion development. Both corticosteroid treatment and depletion of CD4(+) or CD8(+) T cells also resulted in decreased expression of the proinflammatory and profibrotic cytokines, interferon (IFN)-gamma and monocyte chemoattractant protein-1 (MCP-1). Further, treatment of mice with a neutralizing monoclonal antibody to IFN-gamma also significantly inhibited the development of fibrosis. Taken together, these results suggest a significant role for T cells in the development of reovirus 1/L-induced BOOP fibrotic lesions in CBA/J mice and suggests that T(H)1-derived cytokines, especially IFN-gamma, may play a key role in fibrotic lesion development.
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