ArticleThe American journal of pathology2003
Detection of genomic amplification of the human telomerase gene (TERC) in cytologic specimens as a genetic test for the diagnosis of cervical dysplasia.
Article in The American journal of pathology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 126 citations in OpenAlex.
- The significant diagnostic value of human telomerase RNA component (hTERC) gene detection in high-grade cervical lesions and invasive cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Canonical and non-canonical functions of the non-coding RNA component (TERC) of telomerase complex.Cell & bioscience · 2025Review
- Review
- Genome-wide somatic copy number alteration analysis and database construction for cervical cancer.Molecular genetics and genomics : MGG · 2020Article
- Human papillomavirus and human telomerase RNA component gene in cervical cancer progression.Scientific reports · 2019Article
- Induced Chromosomal Aneuploidy Results in Global and Consistent Deregulation of the Transcriptome of Cancer Cells.Neoplasia (New York, N.Y.) · 2019Article
- Molecular mechanisms in progression of HPV-associated cervical carcinogenesis.Journal of biomedical science · 2019Review
- Telomere Maintenance Mechanisms in Cancer.Genes · 2018Review
- Article
- Determination of malignant potential of cervical intraepithelial neoplasia.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Review
- Telomerase and the process of cervical carcinogenesis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Review
- c-myc copy number gain is a powerful prognosticator of disease outcome in cervical dysplasia.Oncotarget · 2015Article
- Expression of the p53 target Wig-1 is associated with HPV status and patient survival in cervical carcinoma.PloS one · 2014Article
- Gene amplification of EGFR and its clinical significance in various cervical (lesions) lesions using cytology and FISH.International journal of clinical and experimental pathology · 2014Article
- Chromosomal gains measured in cytology samples from women with abnormal cervical cancer screening results.Gynecologic oncology · 2013Article
- Detention of HPV L1 Capsid Protein and hTERC Gene in Screening of Cervical Cancer.Iranian journal of basic medical sciences · 2013Article
- Single-cell genetic analysis of ductal carcinoma in situ and invasive breast cancer reveals enormous tumor heterogeneity yet conserved genomic imbalances and gain of MYC during progression.The American journal of pathology · 2012Article
- Genomic amplification of the human telomerase gene (hTERC) associated with human papillomavirus is related to the progression of uterine cervical dysplasia to invasive cancer.Diagnostic pathology · 2012Article
- Significance of micronucleus in cervical intraepithelial lesions and carcinoma.Journal of cytology · 2012Article
- The detection of hTERC amplification using fluorescence in situ hybridization in the diagnosis and prognosis of cervical intraepithelial neoplasia: a case control study.World journal of surgical oncology · 2012Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
Invasive cervical carcinomas frequently reveal additional copies of the long arm of chromosome 3. The detection of this genetic aberration in diagnostic samples could therefore complement the morphological interpretation. We have developed a triple-color DNA probe set for the visualization of chromosomal copy number changes directly in thin-layer cervical cytology slides by fluorescence in situ hybridization. The probe set consists of a BAC contig that contains sequences for the RNA component of the human telomerase gene (TERC) on chromosome band 3q26, and repeat sequences specific for the centromeres of chromosomes 3 and 7 as controls. In a blinded study, we analyzed 57 thin-layer slides that had been rigorously screened and classified as normal (n = 13), atypical squamous cells (ASC, n = 5), low-grade squamous intraepithelial lesions (LSIL, n = 14), and high-grade squamous intraepithelial lesions (HSIL) grade 2 (CIN2, n = 8), and grade 3 (CIN3, n = 17). The percentage of tetraploid cells (P(Trend) < 0.0005) and cells with multiple 3q signals increased with the severity of the cytologic interpretation (P(Trend) < 0.0005). While only few normal samples, ASC and LSIL lesions, revealed copy number increases of 3q, 63% of the HSIL (CIN2) lesions and 76% of the HSIL (CIN3) lesions showed extra copies of 3q. We conclude that the visualization of chromosome 3q copy numbers in routinely prepared cytological material using BAC clones specific for TERC serves as an independent screening test for HSIL and may help to determine the progressive potential of individual lesions.
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