ArticleThe American journal of pathology2003
Estrogen receptor alpha is a novel marker expressed by follicular dendritic cells in lymph nodes and tumor-associated lymphoid infiltrates.
Article in The American journal of pathology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 52 citations in OpenAlex.
- Differential expression of estrogen receptor-α on follicular dendritic cells from patients with grade 1-2 and grade 3 follicular lymphoma.Hematological oncology · 2019Trial
- Increasing estrogen receptor alpha-positive follicular dendritic cells in enlarged germinal centers of IgG4-related sialadenitis.Journal of clinical and experimental hematopathology : JCEH · 2025Article
- Expression of Estrogen Receptors in Main Immune Organs in Sheep During Early Pregnancy.International journal of molecular sciences · 2025Article
- Comparison of juvenile and adult myasthenia gravis in a French cohort with focus on thymic histology.Scientific reports · 2024Article
- Tonsil tissue control is ideal for monitoring estrogen receptor immunohistochemical staining.Journal of the Chinese Medical Association : JCMA · 2023Article
- Progesterone as an Anti-Inflammatory Drug and Immunomodulator: New Aspects in Hormonal Regulation of the Inflammation.Biomolecules · 2022Review
- The Effects of Tamoxifen on Tolerogenic Cells in Cancer.Biology · 2022Review
- Follicular dendritic cell sarcoma.Pathologica · 2021Review
- Immunology of neuromyelitis optica during pregnancy.Neurology(R) neuroimmunology & neuroinflammation · 2016Review
- Oriental medicine Kyung-Ok-Ko prevents and alleviates dehydroepiandrosterone-induced polycystic ovarian syndrome in rats.PloS one · 2014Article
- Endocrine control of mucosal immunity in the female reproductive tract: impact of environmental disruptors.Molecular and cellular endocrinology · 2012Review
- New approaches to making the microenvironment of the female reproductive tract hostile to HIV.American journal of reproductive immunology (New York, N.Y. : 1989) · 2011Review
- Comparison of evaluations of hormone receptors in breast carcinoma by image-analysis using three automated immunohistochemical stainings.Experimental and therapeutic medicine · 2010Article
- Article
- Review
- Involvement of gonadal steroids and gamma interferon in sex differences in response to blood-stage malaria infection.Infection and immunity · 2006Article
- Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During routine assessment of the hormonal phenotype of breast carcinomas, we detected expression of the estrogen receptor (ER) in the germinal centers of reactive lymphoid follicles surrounding malignant foci. To confirm and extend this finding, we compared ER-alpha, progesterone receptor (PR), and androgen receptor (AR) immunostaining in hyperplastic or metastatic lymph nodes obtained from patients with various pathology, disease location, gender and age. Irrespective of these parameters, we found that: 1) ER-alpha-positive cells were located prevalently in germinal centers, 2) the PR was weakly expressed by cells within and surrounding germinal centers, and 3) the androgen receptor was undetectable. Transcripts for ER-alpha and PR were also detected by reverse transcription-polymerase chain reaction on laser-microdissected lymph node germinal centers. Morphologically, the ER-positive cells resemble dendritic cells and by double immunostaining were found to express both CD21 and CD23, which is characteristic of follicular dendritic cells. Finally, we assessed the effects of Tamoxifen treatment by comparing the numbers of ER-positive follicular dendritic cells in lymph nodes obtained from breast cancer patients before and after treatment. The results show that Tamoxifen treatment generated larger germinal centers with more abundant ER(+)/CD21(+)/CD23(+) cells. Taken together, these results open new perspectives on the effects of sex steroids and their antagonists on the human response in cancer and inflammation.
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