ReviewEuropean journal of clinical nutrition2003
Possible roles of magnesium on the immune system.
Review in European journal of clinical nutrition, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
81 citing papers in PubMed, 3 syntheses or guidelines pooled it, 249 citations in OpenAlex.
- Pooled it
- Macro and trace elements signature of periodontitis in saliva: A systematic review with quality assessment of ionomics studies.Journal of periodontal research · 2022Pooled it
- Is Magnesium Supplementation an Effective Nutritional Method to Reduce Stress in Domestic Pigs? A Systematic Review.Frontiers in veterinary science · 2020Pooled it
- Oral magnesium supplementation in asthmatic children: a double-blind randomized placebo-controlled trial.European journal of clinical nutrition · 2007Trial
- Article
- A pilot study on the effect of feed supplementation with magnesium oxide and magnesium aspartate on blood magnesium content and tail lesions in pigs under practical on-farm conditions.Porcine health management · 2026Article
- Effects of Dietary Calcium and Magnesium Levels on the Growth Performance, Tissue Mineral Deposition, Exoskeleton Development, and Molting Performance of Chinese Mitten Crab (Aquaculture nutrition · 2026Article
- Magnesium Promotes Growth-Metabolism Balance in Juvenile Largemouth Bass (Antioxidants (Basel, Switzerland) · 2025Article
- Impact of Iron Overload and Hypomagnesemia Combination on Pediatric Allogeneic Hematopoietic Stem Cell Transplantation Outcomes.Nutrients · 2025Article
- Prevalence, Risk Factors and Potential Protective Strategies for Hypomagnesemia in Kidney Transplant Recipients.International journal of molecular sciences · 2025Article
- Hypomagnesemia in lymphoma patients receiving CAR T therapy correlates with immune dysfunction and decreased survival.Experimental hematology & oncology · 2025Article
- Comparative phytochemical and pharmacological analysis of two cultivars of Annona squamosa L. cultivated in Egypt.NPJ science of food · 2025Article
- Molecular Impact of Magnesium-Mediated Immune Regulation in Diseases.Scientifica · 2025Review
- Investigation of the impact of exposure to trace elements on health and disease from the ToxiLaus study.Scientific reports · 2024Article
- Influence of blood trace elements on immune responses and adverse symptoms subsequent to Sinopharm COVID-19 vaccination.Scientific reports · 2024Article
- Micronutrient interactions: Magnesium and its synergies in maternal-fetal health.Food science & nutrition · 2024Review
- Association of Domestic Water Hardness with All-Cause and Cause-Specific Cancers: Evidence from 447,996 UK Biobank Participants.Environmental health perspectives · 2024Article
- Magnesium and the Hallmarks of Aging.Nutrients · 2024Review
- Association between dietary magnesium intake and pelvic inflammatory disease in US women: a cross-sectional study of NHANES.Frontiers in nutrition · 2024Article
- Explorations on the antiviral potential of zinc and magnesium salts against chikungunya virus: implications for therapeutics.Frontiers in cellular and infection microbiology · 2024Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the last few years, magnesium (Mg) has been subject of research due to its functionality in the organism. It is one of the most important micronutrients, and therefore its role in biological systems has been extensively investigated. Particularly, Mg has a strong relation with the immune system, in both nonspecific and specific immune response, also known as innate and acquired immune response. The aim of this paper is to review the state of the art about the interactions between Mg and the immune system. We discuss the link between dietary Mg and inflammation, apoptosis and alterations in number and function of innate immune cell populations, described in animal models. Furthermore, the immune system can be compromised in human populations under certain circumstances, including athletes and elderly people. The importance of a balanced Mg homeostasis and its interaction with the immune system in these groups has also been reviewed. Although emerging data support the relevant role of Mg in the immune response, further research is needed; and special efforts should be made to establish the most adequate dose in nutritional supplements to reach beneficial effects on health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.