Evidence map›Paper›PMID 14506055›Full record

ArticleAntimicrobial agents and chemotherapy2003

Ciprofloxacin transport by chemoattractant-activated polymorphonuclear leukocytes: regulation by priming and protein kinase C.

John D Walters, Robin J Nakkula

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Can we produce an image of bacteria with radiopharmaceuticals?European journal of nuclear medicine and molecular imaging · 2008
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

John D WaltersSection of Periodontology, College of Dentistry, The Ohio State University Health Sciences Center, Columbus, Ohio 43218-2357, USA. walters.2@osu.edu
Robin J Nakkula
The Ohio State University · US

Funding

Uptake of Fluoroquinolones and Tetracyclines by GingivaR01DE012601 · NIDCR · OHIO STATE UNIVERSITY · PI WALTERS, JOHN DOUGLAS · 1998 to 2003
$744k
NIDCR NIH HHS R01 DE012601NIDCR NIH HHS R01 DE12601
6 · The paper itself

Abstract

At infection sites, polymorphonuclear leukocyte (PMN) function is enhanced ("primed") by granulocyte-macrophage colony-stimulating factor (GM-CSF) or lipopolysaccharide (LPS) and activated by formyl peptides. In this study, GM-CSF or LPS alone had no significant effects on PMN ciprofloxacin transport. Through a mechanism involving protein kinase C, activation by formyl-Met-Leu-Phe (fMLP) significantly decreased the K(m) of ciprofloxacin transport and enhanced ciprofloxacin accumulation. This effect was dramatically enhanced when PMNs were primed with GM-CSF or LPS prior to activation by fMLP.

Indexed as

Biological TransportCalciumChelating AgentsChemotactic FactorsCiprofloxacinDiacylglycerol KinaseDrug SynergismEnzyme ActivationEnzyme InhibitorsGranulocyte-Macrophage Colony-Stimulating FactorHumansLipopolysaccharidesNeutrophilsN-Formylmethionine Leucyl-PhenylalanineProtein Kinase CCalciumChelating AgentsChemotactic FactorsCiprofloxacinDiacylglycerol KinaseEnzyme InhibitorsGranulocyte-Macrophage Colony-Stimulating FactorLipopolysaccharidesN-Formylmethionine Leucyl-PhenylalanineProtein Kinase C

Identifiers

PMID14506055
PMCPMC201116
OpenAlexW2119916447

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.