ArticleAntimicrobial agents and chemotherapy2003
Multilaboratory comparison of proficiencies in susceptibility testing of Helicobacter pylori and correlation between agar dilution and E test methods.
Article in Antimicrobial agents and chemotherapy, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 57 citations in OpenAlex.
- Minocycline vs. tetracycline in bismuth-containing quadruple therapy for Helicobacter pylori rescue treatment: a multicentre, randomized controlled trial.Journal of gastroenterology · 2023Trial
- 14-Day High-Dose Amoxicillin- and Metronidazole-Containing Triple Therapy With or Without Bismuth as First-Line Helicobacter pylori Treatment.Digestive diseases and sciences · 2020Trial
- Review
- Helicobacter pylori antimicrobial resistance and gene variants in Shandong Province.Scientific reports · 2025Article
- [Comparison of Epsilometer test and agar dilution method in detecting the sensitivity ofBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2023Article
- Multicenter Evaluation of a Gradient Diffusion Method for Antimicrobial Susceptibility Testing of Helicobacter pylori.Microbiology spectrum · 2022Article
- Efficacy of Disc Diffusion and Agar Dilution Methods in EvaluatingMiddle East journal of digestive diseases · 2022Article
- Increased Antibiotic Resistance in Children withPathogens (Basel, Switzerland) · 2022Article
- Sociodemographic characteristics and clinical risk factors of Helicobacter pylori infection and antibiotic resistance in the Eastern Black Sea region of Turkey.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2020Article
- E-test versus agar dilution for antibiotic susceptibility testing of Helicobacter pylori: a comparison study.BMC research notes · 2020Article
- Daphnetin: A Novel Anti-International journal of molecular sciences · 2019Article
- Association of hp1181 and hp1184 Genes With the Active Efflux Phenotype in Multidrug-Resistant Isolates of Helicobacter pylori.Jundishapur journal of microbiology · 2016Article
- Antimicrobial susceptibility testing for Helicobacter pylori isolates from Brazilian children and adolescents: comparing agar dilution, E-test, and disk diffusion.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2014Article
- Validation of a fluorescence in situ hybridization method using peptide nucleic acid probes for detection of Helicobacter pylori clarithromycin resistance in gastric biopsy specimens.Journal of clinical microbiology · 2013Article
- Antimicrobial susceptibility of Helicobacter pylori strains isolated from patients in Shiraz, Southern Iran.World journal of gastroenterology · 2010Article
- Rescue therapy using a rifabutin-based regimen is effective for cure of Helicobacter pylori infection.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2010Article
- Pyrosequencing assay to rapidly detect clarithromycin resistance mutations in Canadian Helicobacter pylori isolates.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2009Article
- Antimicrobial susceptibility and mutations involved in clarithromycin resistance in Helicobacter pylori isolates from patients in the western central region of Colombia.Antimicrobial agents and chemotherapy · 2009Article
- Evaluation of seaFAST, a rapid fluorescent in situ hybridization test, for detection of Helicobacter pylori and resistance to clarithromycin in paraffin-embedded biopsy sections.Journal of clinical microbiology · 2005Article
Corrections and comments
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Authors and funding
15 authors at 8 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Susceptibility testing was performed at seven Canadian microbiology laboratories and the Helicobacter Reference Laboratory, Halifax, Nova Scotia, Canada, to assess susceptibility testing proficiency and the reproducibility of the results for clarithromycin and metronidazole and to compare the Epsilometer test (E test) method to the agar dilution reference method. Control strain Helicobacter pylori ATCC 43504 (American Type Culture Collection) and 13 clinical isolates (plus duplicates of four of these strains including ATCC 43504) were tested blindly. The National Committee for Clinical Laboratory Standards (NCCLS) guidelines for agar dilution testing were followed, and the same suspension of organisms was used for agar dilution and E test. Antimicrobials and E test strips were provided to the investigators. Methods were provided on a website (www.Helicobactercanada.org). Each center reported MICs within the stated range for strain ATCC 43504. Compared to the average MICs, interlaboratory agreements within 2 log(2) dilutions were 90% (range, 69 to 100%) for clarithromycin by agar dilution, with seven very major errors [VMEs], and 85% (range, 65 to 100%) by E test, with three VMEs. Interlaboratory agreements within 2 log(2) dilutions were 83% (range, 50 to 100%) for metronidazole by agar dilution, with six VMEs and eight major errors (MEs), and 75% (range, 50 to 94%) by E test, with four VMEs and four MEs. At lower and higher concentrations of antibiotic, E test MICs were slightly different from agar dilution MICs, but these differences did not result in errors. When a standardized protocol based on NCCLS guidelines was used, most participants in this study correctly identified clarithromycin- and metronidazole-susceptible and -resistant strains of H. pylori 93% of the time by either the agar dilution or E test method, and the numbers of errors were relatively equivalent by both methods.
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