Evidence map›Paper›PMID 14506013›Full record

ArticleAntimicrobial agents and chemotherapy2003

In vitro activities of three licensed antifungal agents against spanish clinical isolates of Aspergillus spp.

Alicia Gomez-Lopez, Guillermo Garcia-Effron, Emilia Mellado, Araceli Monzon, Juan L Rodriguez-Tudela, Manuel Cuenca-Estrella

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 82 citations in OpenAlex.

  1. Review
  2. Amphotericin B ResistantInfectious diseases & clinical microbiology · 2024
    Article
  3. Article
  4. Article
  5. Infection and drug resistance · 2020
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  19. Efflux-mediated antifungal drug resistance.Clinical microbiology reviews · 2009
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Alicia Gomez-LopezUnidad de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain. mcuenca-estrella@isciii.es
Guillermo Garcia-Effron
Emilia Mellado
Araceli Monzon
Juan L Rodriguez-Tudela
Manuel Cuenca-Estrella
Instituto de Salud Carlos III · ESCentro Nacional de Microbiologia · ESNational University of the Littoral · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the present study was to identify retrospectively trends in the species distributions and the susceptibility patterns of Aspergillus species causing fungal infections in Spanish medical centers from 2000 to 2002. The susceptibilities of 338 isolates to amphotericin B, itraconazole, and voriconazole were tested. Aspergillus fumigatus was the most common species (54.7%), followed by Aspergillus terreus (14.8%) and Aspergillus flavus (13.9%). Non-A. fumigatus species were encountered in 45.3% of the samples studied. The majority of Aspergillus isolates were obtained from respiratory tract specimens, followed by ear and skin samples. The geometric mean (GM) MIC of amphotericin B was 0.56 micro g/ml, and the amphotericin B MIC was >2 micro g/ml for 16 isolates (4.7%). Nine of them were A. terreus. The GM MIC of itraconazole was 0.37, and the itraconazole MIC was >4 micro g/ml for 12 (3.5%) isolates. The voriconazole MICs were also high for 8 of the 12 strains for which itraconazole MICs were high (voriconazole MIC range, 2 to 8 micro g/ml).

Indexed as

Amphotericin BAntifungal AgentsAspergillosisAspergillusHumansItraconazoleMicrobial Sensitivity TestsPyrimidinesRetrospective StudiesSpainTriazolesVoriconazoleAmphotericin BAntifungal AgentsItraconazolePyrimidinesTriazolesVoriconazole

Identifiers

PMID14506013
PMCPMC201144
OpenAlexW2015576282

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.