ArticleIn vitro cellular & developmental biology. Animal
Characterization of newly established clonal oviductal cell lines and differential hormonal regulation of gene expression.
Article in In vitro cellular & developmental biology. Animal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 33 citations in OpenAlex.
- Replication stress and defective checkpoints make fallopian tube epithelial cells putative drivers of high-grade serous ovarian cancer.Cell reports · 2023Article
- A clonal stem cell line established from a mouse mammary placode with ability to generate functional mammary glands.In vitro cellular & developmental biology. Animal · 2019Article
- Establishment of a new immortalized human corneal epithelial cell line (iHCE-NY1) for use in evaluating eye irritancy by in vitro test methods.In vitro cellular & developmental biology. Animal · 2016Article
- Article
- The impact of ovulation on fallopian tube epithelial cells: evaluating three hypotheses connecting ovulation and serous ovarian cancer.Endocrine-related cancer · 2011Article
- Evaluating the progenitor cells of ovarian cancer: analysis of current animal models.BMB reports · 2011Review
- Alginate hydrogels for three-dimensional organ culture of ovaries and oviducts.Journal of visualized experiments : JoVE · 2011Article
- Establishment of clonal cell lines of taste buds from a p53(-/-) mouse tongue.In vitro cellular & developmental biology. Animal · 2011Article
- Newly established cell lines from mouse oral epithelium regenerate teeth when combined with dental mesenchyme.In vitro cellular & developmental biology. Animal · 2010Article
- Follistatin-like-1, a diffusible mesenchymal factor determines the fate of epithelium.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Ovarian cancer pathogenesis: a model in evolution.Journal of oncology · 2010Article
- Recent advances in the understanding of the pathogenesis of serous carcinoma: the concept of low- and high-grade disease and the role of the fallopian tube.Diagnostic histopathology (Oxford, England) · 2008Article
- Establishment and characterization of female reproductive tract epithelial cell culture.Journal of microscopy and ultrastructureArticle
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oviductal functions have been studied mainly in primary epithelial cell culture and organ culture. However, secretory cells and ciliated cells coexist in the epithelium, and the small size of the oviduct limits the sources of both epithelial and stromal cells. To circumvent the limits, we attempted to establish clonal cell lines from an oviduct of a p53-deficient mouse. An oviduct was enzymatically digested and cultured in medium containing 10% fetal calf serum supplemented with estradiol-17beta. Morphologically distinct clones (10 epithelial and 4 fibroblastic clones) were established, and all clones expressed estrogen receptor alpha and progesterone receptor. Expression of a mouse oviduct-specific glycoprotein gene as a marker of secretory cells was limited in one clone and was stimulated by estrogens and suppressed by progesterone. Expression of helix factor hepatocyte nuclear factor/forkhead homologue-4 gene as a marker of ciliated cells was limited in two clones and was suppressed by estrogens. The two genes were never coexpressed in any clones. The results strongly suggest that the oviductal epithelium consists of two functionally determined populations. To our knowledge, this is the first establishment of functional clonal cell lines of the oviduct and makes it possible to study independently two oviductal functions, secretion and ciliogenesis.
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