ArticleProceedings of the National Academy of Sciences of the United States of America2003
The BCSC-1 locus at chromosome 11q23-q24 is a candidate tumor suppressor gene.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 53 citations in OpenAlex.
- Mapping the BCSC-1 interactome in breast cancer.Scientific reports · 2025Article
- Loss of Predicted Cell Adhesion Molecule MPZL3 Promotes EMT in Ovarian Cancer.Cancer research communications · 2025Article
- Pan-Cancer Analysis of the Prognostic and Immunological Role of TOMM40 to Identify Its Function in Breast Cancer.Biochemical genetics · 2025Article
- Identification of VWA5A as a novel biomarker for inhibiting metastasis in breast cancer by machine-learning based protein prioritization.Scientific reports · 2024Article
- Synergy between a cytoplasmic vWFA/VIT protein and a WD40-repeat F-box protein controls development inFrontiers in cell and developmental biology · 2023Article
- The Rattlesnake W Chromosome: A GC-Rich Retroelement Refugium with Retained Gene Function Across Ancient Evolutionary Strata.Genome biology and evolution · 2022Article
- Molecular Biological Comparison of Dental Pulp- and Apical Papilla-Derived Stem Cells.International journal of molecular sciences · 2022Article
- Human Tumor Targeted Cytotoxic Mast Cells for Cancer Immunotherapy.Frontiers in oncology · 2022Article
- Mortality and cancer incidence in carriers of constitutional t(11;22)(q23;q11) translocations: A prospective study.International journal of cancer · 2019Article
- Association of BCSC-1 and MMP-14 with human breast cancer.Oncology letters · 2018Article
- Perturbations of PIP3 signalling trigger a global remodelling of mRNA landscape and reveal a transcriptional feedback loop.Nucleic acids research · 2015Article
- Inbreeding and homozygosity in breast cancer survival.Scientific reports · 2015Article
- High expression of kinesin light chain-2, a novel target of miR-125b, is associated with poor clinical outcome of elderly non-small-cell lung cancer patients.British journal of cancer · 2015Article
- MTA1 promotes the invasion and migration of non-small cell lung cancer cells by downregulating miR-125b.Journal of experimental & clinical cancer research : CR · 2013Article
- Pioneering the Xenopus oocyte and egg extract system.The Journal of biological chemistry · 2012Article
- Frequent alterations of LOH11CR2A, PIG8 and CHEK1 genes at chromosomal 11q24.1-24.2 region in breast carcinoma: clinical and prognostic implications.Molecular oncology · 2011Article
- Frequent loss of the BLID gene in early-onset breast cancer.Cytogenetic and genome research · 2011Article
- 11q21.1-11q23.3 Is a site of intrinsic genomic instability triggered by irradiation.Genes, chromosomes & cancer · 2010Article
- Comprehensive analysis of MHC class I genes from the U-, S-, and Z-lineages in Atlantic salmon.BMC genomics · 2010Article
- LARG at chromosome 11q23 has functional characteristics of a tumor suppressor in human breast and colorectal cancer.Oncogene · 2009Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Frequent allelic loss at human chromosome 11q23-q24 occurs in a wide variety of cancers, suggesting that this region may harbor a tumor suppressor gene. By constructing a physical map of the LOH11CR2 minimal region of loss on 11q23-q24 associated with lung and breast carcinomas, we were able to clone a hereditary translocation, t(11;12)(q23;q24), in a patient with early-onset breast cancer and family history of cancer. The breakpoint was found within 6 kb of the BCSC-1 candidate tumor suppressor gene located in the LOH11CR2 region whereas additional loss of heterozygosity (LOH) analysis in breast and ovarian tumors, including that of the patient with the t(11;12)(q23;q24), implicated the BCSC-1 locus as the primary target of deletion. Northern analysis of the BCSC-1 mRNA revealed a lack of expression in 33 of 41 (80%) tumor cell lines, and its ectopic expression led to the suppression of colony formation in vitro and tumorigenicity in vivo. These data suggest that BCSC-1 may exert a tumor suppressor activity and is a likely target of the LOH observed on 11q23-q24 in cancer.
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