ArticleGenetics2003
A method for detecting recent selection in the human genome from allele age estimates.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Improved reference genome of the arboviral vector Aedes albopictus.Genome biology · 2020Article
- Nutrition and Genetics in NAFLD: The Perfect Binomium.International journal of molecular sciences · 2020Review
- The evolutionary adaptation of the C282Y mutation to culture and climate during the European Neolithic.American journal of physical anthropology · 2016Article
- Signatures of Evolutionary Adaptation in Quantitative Trait Loci Influencing Trace Element Homeostasis in Liver.Molecular biology and evolution · 2016Article
- Review
- Natural selection on HFE in Asian populations contributes to enhanced non-heme iron absorption.BMC genetics · 2015Article
- A Composite-Likelihood Method for Detecting Incomplete Selective Sweep from Population Genomic Data.Genetics · 2015Article
- Aging and liver disease.Current opinion in gastroenterology · 2015Review
- Molecular population genetics of inversion breakpoint regions in Drosophila pseudoobscura.G3 (Bethesda, Md.) · 2013Article
- Iron and diabetes risk.Cell metabolism · 2013Review
- Human genomic disease variants: a neutral evolutionary explanation.Genome research · 2012Review
- A powerful score test to detect positive selection in genome-wide scans.European journal of human genetics : EJHG · 2010Article
- An investigation of the statistical power of neutrality tests based on comparative and population genetic data.Molecular biology and evolution · 2009Article
- Genetic and epigenetic contributions to human nutrition and health: managing genome-diet interactions.Journal of the American Dietetic Association · 2008Review
- Article
- Complex signatures of selection and gene conversion in the duplicated globin genes of house mice.Genetics · 2007Article
- Localizing recent adaptive evolution in the human genome.PLoS genetics · 2007Article
- Forward-time simulations of human populations with complex diseases.PLoS genetics · 2007Article
- Human adaptive evolution at Myostatin (GDF8), a regulator of muscle growth.American journal of human genetics · 2006Article
- A nonparametric test reveals selection for rapid flowering in the Arabidopsis genome.PLoS biology · 2006Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Mutations that have recently increased in frequency by positive natural selection are an important component of naturally occurring variation that affects fitness. To identify such variants, we developed a method to test for recent selection by estimating the age of an allele from the extent of haplotype sharing at linked sites. Neutral coalescent simulations are then used to determine the likelihood of this age given the allele's observed frequency. We applied this method to a common disease allele, the hemochromatosis-associated HFE C282Y mutation. Our results allow us to reject neutral models incorporating plausible human demographic histories for HFE C282Y and one other young but common allele, indicating positive selection at HFE or a linked locus. This method will be useful for scanning the human genome for alleles under selection using the haplotype map now being constructed.
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