ArticleGenetics2003
Mapping modifiers affecting muscularity of the myostatin mutant (Mstn(Cmpt-dl1Abc)) compact mouse.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Stanniocalcin-2 inhibits skeletal muscle growth and is upregulated in functional overload-induced hypertrophy.Physiological reports · 2023Article
- A Sensitive and Selective Immunoassay for the Quantitation of Serum Latent Myostatin after In Vivo Administration of SRK-015, a Selective Inhibitor of Myostatin Activation.SLAS discovery : advancing life sciences R & D · 2020Article
- Blocking extracellular activation of myostatin as a strategy for treating muscle wasting.Scientific reports · 2018Article
- SOCE Is Important for Maintaining Sarcoplasmic Calcium Content and Release in Skeletal Muscle Fibers.Biophysical journal · 2017Article
- Skeletal muscle cellularity and glycogen distribution in the hypermuscular Compact mice.European journal of histochemistry : EJH · 2014Article
- Hypermuscular mice with mutation in the myostatin gene display altered calcium signalling.The Journal of physiology · 2014Article
- The compact mutation of myostatin causes a glycolytic shift in the phenotype of fast skeletal muscles.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2013Article
- Body composition and gene expression QTL mapping in mice reveals imprinting and interaction effects.BMC genetics · 2013Article
- Genetic and genomic analyses of musculoskeletal differences between BEH and BEL strains.Physiological genomics · 2013Article
- Analyses of muscle spindles in the soleus of six inbred mouse strains.Journal of anatomy · 2013Article
- Effect of the myostatin locus on muscle mass and intramuscular fat content in a cross between mouse lines selected for hypermuscularity.BMC genomics · 2013Article
- Article
- A modifier locus on chromosome 5 contributes to L1 cell adhesion molecule X-linked hydrocephalus in mice.Neurogenetics · 2010Article
- Mapping multiple quantitative trait loci under Bayes error control.Genetics research · 2009Article
- Clinical, agricultural, and evolutionary biology of myostatin: a comparative review.Endocrine reviews · 2008Review
- Genetic determinants of weight of fast- and slow-twitch skeletal muscles in old mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2006Article
- Genome-wide isolation of growth and obesity QTL using mouse speed congenic strains.BMC genomics · 2006Article
- Effects of the compact mutant myostatin allele Mstn (Cmpt-dl1Abc) introgressed into a high growth mouse line on skeletal muscle cellularity.Journal of muscle research and cell motility · 2005Article
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hypermuscular Compact phenotype was first noted in a line of mice selected for high body weight and protein content. A new line, based on mice showing the Compact phenotype, was formed and selected for maximum expression of the Compact phenotype. Previously we mapped and identified a 12-bp deletion in the myostatin gene, denoted Mstn(Cmpt-dl1Abc), which can be considered as a major gene responsible for the hypermuscular phenotype. Genetic analysis revealed that full expression of the hypermuscular phenotype requires the action of modifier loci in addition to Mstn(Cmpt-dl1Abc). To map these modifier loci, an interspecific F(2) population was generated between Comp9, an inbred line homozygous for Mstn(Cmpt-dl1Abc), and CAST/Ei, an inbred line generated from Mus musculus castaneus. Selective DNA pooling and genotyping, separately by gender, was carried out within a subpopulation of the F(2) consisting of individuals homozygous for Mstn(Cmpt-dl1Abc). Significant association with hypermuscularity at a false discovery rate (FDR) of 0.05 was found for markers on chromosomes 3, 5, 7, 11, 16, and X. In all cases, the marker allele derived from the Comp9 parent showed a higher frequency in the hypermuscular group and the CAST/Ei allele in the normal group. The modifier loci apparently exerted their effects on muscularity only in the presence of Mstn(Cmpt-dl1Abc).
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