ArticleGenetics2003
Identification of Cis-regulatory elements in the mouse Pax9/Nkx2-9 genomic region: implication for evolutionary conserved synteny.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
- International Registry of NKX2-1-Related Disorders: Clinical, Genetic, and Imaging Perspectives.Movement disorders : official journal of the Movement Disorder Society · 2026Observational
- De novo draft assembly of the Botrylloides leachii genome provides further insight into tunicate evolution.Scientific reports · 2018Article
- Developmental History Provides a Roadmap for the Emergence of Tumor Plasticity.Developmental cell · 2018Article
- Evidence from cyclostomes for complex regionalization of the ancestral vertebrate brain.Nature · 2016Article
- Hemichordate genomes and deuterostome origins.Nature · 2015Article
- Comprehensive genotyping and clinical characterisation reveal 27 novel NKX2-1 mutations and expand the phenotypic spectrum.Journal of medical genetics · 2014Article
- Targeting of Slc25a21 is associated with orofacial defects and otitis media due to disrupted expression of a neighbouring gene.PloS one · 2014Article
- Article
- Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning.Genes & development · 2012Article
- Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors.Development (Cambridge, England) · 2012Article
- Identification of a Novel 14q13.3 Deletion Involving the SLC25A21 Gene Associated with Familial Synpolydactyly.Molecular syndromology · 2012Article
- Regulatory genomics: Insights from the zebrafish.Current topics in genetics · 2012Article
- An evolutionarily conserved enhancer regulates Bmp4 expression in developing incisor and limb bud.PloS one · 2012Article
- MotifMap: integrative genome-wide maps of regulatory motif sites for model species.BMC bioinformatics · 2011Article
- Genetic variation among major human geographic groups supports a peculiar evolutionary trend in PAX9.PloS one · 2011Article
- A transposon-based chromosomal engineering method to survey a large cis-regulatory landscape in mice.Nature genetics · 2009Article
- Variable locus length in the human genome leads to ascertainment bias in functional inference for non-coding elements.Bioinformatics (Oxford, England) · 2009Article
- Assaying the regulatory potential of mammalian conserved non-coding sequences in human cells.Genome biology · 2008Article
- The Fugu tyrp1 promoter directs specific GFP expression in zebrafish: tools to study the RPE and the neural crest-derived melanophores.Pigment cell research · 2006Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We previously reported close physical linkage between Pax9 and Nkx2-9 in the human, mouse, and pufferfish (Fugu rubripes) genomes. In this study, we analyzed cis-regulatory elements of the two genes by comparative sequencing in the three species and by transgenesis in the mouse. We identified two regions including conserved noncoding sequences that possessed specific enhancer activities for expression of Pax9 in the medial nasal process and of Nkx2-9 in the ventral neural tube. Remarkably, the latter contained the consensus Gli-binding motif. Interestingly, the identified Pax9 cis-regulatory sequences were located in an intron of the neighboring gene Slc25a21. Close examination of an extended genomic interval around Pax9 revealed the presence of strong synteny conservation in the human, mouse, and Fugu genomes. We propose such an intersecting organization of cis-regulatory sequences in multigenic regions as a possible mechanism that maintains evolutionary conserved synteny.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.