ArticleGenetics2003
A targeted histone acetyltransferase can create a sizable region of hyperacetylated chromatin and counteract the propagation of transcriptionally silent chromatin.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Large scale analysis of co-existing post-translational modifications in histone tails reveals global fine structure of cross-talk.Molecular & cellular proteomics : MCP · 2014Article
- A computational model for histone mark propagation reproduces the distribution of heterochromatin in different human cell types.PloS one · 2013Article
- Genome-wide prediction and analysis of human chromatin boundary elements.Nucleic acids research · 2012Article
- Roles of chromatin remodeling factors in the formation and maintenance of heterochromatin structure.The Journal of biological chemistry · 2011Article
- Dot1 binding induces chromatin rearrangements by histone methylation-dependent and -independent mechanisms.Epigenetics & chromatin · 2011Article
- Histone H4 lysine 12 acetylation regulates telomeric heterochromatin plasticity in Saccharomyces cerevisiae.PLoS genetics · 2011Article
- SWR1 complex poises heterochromatin boundaries for antisilencing activity propagation.Molecular and cellular biology · 2010Article
- Saccharomyces cerevisiae Esc2p interacts with Sir2p through a small ubiquitin-like modifier (SUMO)-binding motif and regulates transcriptionally silent chromatin in a locus-dependent manner.The Journal of biological chemistry · 2010Article
- The SAGA subunit Ada2 functions in transcriptional silencing.Molecular and cellular biology · 2009Article
- Article
- Histone deacetylase Rpd3 antagonizes Sir2-dependent silent chromatin propagation.Nucleic acids research · 2009Article
- Saccharomyces cerevisiae linker histone Hho1p functionally interacts with core histone H4 and negatively regulates the establishment of transcriptionally silent chromatin.The Journal of biological chemistry · 2009Article
- Different functional modes of p300 in activation of RNA polymerase III transcription from chromatin templates.Molecular and cellular biology · 2008Article
- An RNA polymerase III-dependent heterochromatin barrier at fission yeast centromere 1.PloS one · 2007Article
- Asymmetric positioning of nucleosomes and directional establishment of transcriptionally silent chromatin by Saccharomyces cerevisiae silencers.Molecular and cellular biology · 2006Article
- Article
- Ubp10/Dot4p regulates the persistence of ubiquitinated histone H2B: distinct roles in telomeric silencing and general chromatin.Molecular and cellular biology · 2005Article
- Molecular requirements for gene expression mediated by targeted histone acetyltransferases.Molecular and cellular biology · 2004Article
- Formation of boundaries of transcriptionally silent chromatin by nucleosome-excluding structures.Molecular and cellular biology · 2004Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Transcriptionally silent chromatin is associated with reduced histone acetylation and its propagation depends on histone hypoacetylation promoted by histone deacetylases. We show that tethered histone acetyltransferase (HAT) Esa1p or Gcn5p creates a segment of hyperacetylated chromatin that is at least 2.6 kb in size and counteracts transcriptional silencing that emanates from a silencer in yeast. Esa1p and Gcn5p counteract URA3 silencing even when they are targeted 1.7 kb downstream of the promoter and >2.0 kb from the silencer. The anti-silencing effect of a targeted HAT is strengthened by increasing the number of targeting sites, but impaired by events that enhance silencing. A tethered HAT can also counteract telomeric silencing. The anti-silencing effect of Gcn5p is abolished by a mutation that eliminated its HAT activity or by deleting the ADA2 gene encoding a structural component of Gcn5p-containing HAT complexes. These results demonstrate that a tethered HAT complex can create a sizable region of histone hyperacetylation and serve as a barrier to encroaching repressive chromatin.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.