ArticleThe Journal of membrane biology2003
Regulation of the expression of the prostate-specific antigen by claudin-7.
Article in The Journal of membrane biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 48 citations in OpenAlex.
- Cell type-specific genetic regulation of gene expression across human tissues.Science (New York, N.Y.) · 2020Article
- Intratumor δ-catenin heterogeneity driven by genomic rearrangement dictates growth factor dependent prostate cancer progression.Oncogene · 2020Article
- Clinical and Ultrastructural Studies of Gelatinous Drop-Like Corneal Dystrophy (GDLD) of a Patient withJournal of ophthalmology · 2019Article
- Two common human CLDN5 alleles encode different open reading frames but produce one protein isoform.Annals of the New York Academy of Sciences · 2017Article
- Roles of the first-generation claudin binder, Clostridium perfringens enterotoxin, in the diagnosis and claudin-targeted treatment of epithelium-derived cancers.Pflugers Archiv : European journal of physiology · 2017Review
- Lentiviral vector-mediated insertional mutagenesis screen identifies genes that influence androgen independent prostate cancer progression and predict clinical outcome.Molecular carcinogenesis · 2016Article
- Type 1 Insulin-Like Growth Factor Receptor/Insulin Receptor Substrate 1 Signaling Confers Pathogenic Activity on Breast Tumor Cells Lacking REST.Molecular and cellular biology · 2015Article
- Emerging multifunctional roles of Claudin tight junction proteins in bone.Endocrinology · 2014Review
- The distinct expression patterns of claudin-2, -6, and -11 between human gastric neoplasms and adjacent non-neoplastic tissues.Diagnostic pathology · 2013Article
- Claudins and the modulation of tight junction permeability.Physiological reviews · 2013Review
- Molecular networks of human muscle adaptation to exercise and age.PLoS genetics · 2013Article
- [The clinical significance of Claudin-7 and slug expression in lung squamous cell carcinoma and adenocarcinoma].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2011Article
- Article
- The molecular signature of endometriosis-associated endometrioid ovarian cancer differs significantly from endometriosis-independent endometrioid ovarian cancer.Fertility and sterility · 2010Article
- Correlation between Claudins Expression and Prognostic Factors in Prostate Cancer.Korean journal of urology · 2010Article
- Distribution and expression pattern of claudins 6, 7, and 9 in diffuse- and intestinal-type gastric adenocarcinomas.Journal of gastrointestinal cancer · 2010Article
- Expression patterns of claudin family of tight-junction proteins in the mouse prostate.Histochemistry and cell biology · 2007Article
- Claudin-7 is highly expressed in chromophobe renal cell carcinoma and renal oncocytoma.Journal of Korean medical science · 2007Article
- Involvement of claudin-7 in HIV infection of CD4(-) cells.Retrovirology · 2005Article
- Expression of tight-junction protein claudin-7 is an early event in gastric tumorigenesis.The American journal of pathology · 2005Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Claudins are a family of proteins involved in forming tight junctions between cells. Here we describe two forms of claudin-7 (CLDN-7), a full-length form of CLDN-7 with 211 amino-acid residues and a C-terminal truncated form with 158 amino-acid residues. These two forms of CLDN-7 are able to regulate the expression of a tissue-specific protein, the prostate-specific antigen (PSA), in the LNCaP prostate cancer cell line. We also found that the expression of CLDN-7 is responsive to androgen stimulation in the LNCaP cell line, suggesting that this protein is involved in the regulatory mechanism of androgen. Both forms of claudin-7 are expressed in human prostate, kidney and lung samples, and in most samples, the full-length form of claudin-7 was predominant. However, in some prostate samples from healthy individuals, the truncated form of claudin-7 is predominantly expressed. Our results demonstrated that unlike other claudins, CLDN-7 has both structural and regulatory functions, and the two forms of CLDN-7 may be related to cell differentiation in organ development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.