ReviewThe Journal of membrane biology2003
Properties, expression and potential roles of cardiac K+ channel accessory subunits: MinK, MiRPs, KChIP, and KChAP.
Review in The Journal of membrane biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed.
- SUMOylation of the Kv4.2 Ternary Complex Increases Surface Expression and Current Amplitude by Reducing Internalization in HEK 293 Cells.Frontiers in molecular neuroscience · 2021Article
- Use of whole exome sequencing for the identification of Ito-based arrhythmia mechanism and therapy.Journal of the American Heart Association · 2015Article
- Ionic mechanisms limiting cardiac repolarization reserve in humans compared to dogs.The Journal of physiology · 2013Article
- Unique cardiac Purkinje fiber transient outward current β-subunit composition: a potential molecular link to idiopathic ventricular fibrillation.Circulation research · 2013Article
- Trafficking of an endogenous potassium channel in adult ventricular myocytes.American journal of physiology. Cell physiology · 2012Article
- Benchmarking electrophysiological models of human atrial myocytes.Frontiers in physiology · 2012Article
- Role of the ubiquitin system in regulating ion transport.Pflugers Archiv : European journal of physiology · 2011Article
- Properties of WT and mutant hERG K(+) channels expressed in neonatal mouse cardiomyocytes.American journal of physiology. Heart and circulatory physiology · 2010Article
- Larger transient outward K(+) current and shorter action potential duration in Galpha(11) mutant mice.Pflugers Archiv : European journal of physiology · 2010Article
- Closed-state inactivation in Kv4.3 isoforms is differentially modulated by protein kinase C.American journal of physiology. Cell physiology · 2009Article
- The transmembrane beta-subunits KCNE1, KCNE2, and DPP6 modify pharmacological effects of the antiarrhythmic agent tedisamil on the transient outward current Ito.Naunyn-Schmiedeberg's archives of pharmacology · 2009Article
- VAMP2 interacts directly with the N terminus of Kv2.1 to enhance channel inactivation.Pflugers Archiv : European journal of physiology · 2008Article
- Effects of MiRP1 and DPP6 beta-subunits on the blockade induced by flecainide of Kv4.3/KChIP2 channels.British journal of pharmacology · 2008Article
- Article
- Total chemical synthesis and biophysical characterization of the minimal isoform of the KChIP2 potassium channel regulatory subunit.Protein science : a publication of the Protein Society · 2007Article
- Regional and tissue specific transcript signatures of ion channel genes in the non-diseased human heart.The Journal of physiology · 2007Article
- Biophysical and pharmacological properties of the voltage-gated potassium current of human pancreatic beta-cells.The Journal of physiology · 2005Article
- Expression and function of dipeptidyl-aminopeptidase-like protein 6 as a putative beta-subunit of human cardiac transient outward current encoded by Kv4.3.The Journal of physiology · 2005Article
- Voltage dependence of ATP-dependent K+ current in rat cardiac myocytes is affected by IK1 and IK(ACh).The Journal of physiology · 2004Article
- The Kv4.2 N-terminal restores fast inactivation and confers KChlP2 modulatory effects on N-terminal-deleted Kv1.4 channels.Pflugers Archiv : European journal of physiology · 2004Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over the past 10 years, cDNAs encoding a wide range of pore-forming K(+)-channel alpha-subunits have been cloned and found to result in currents with many properties of endogenous cardiac K(+) channels upon homomeric expression in heterologous systems. However, a variety of remaining discrepancies have led to a search for other subunits that might be involved in the formation of native channels. Over the past few years, a series of accessory subunits has been discovered that modify current properties upon coexpression with alpha-subunits. One of these, the minimal K(+)-channel subunit minK, is essential for formation of the cardiac slow delayed-rectifier K(+) current, I(Ks), and may also interact in functionally important ways with other alpha-subunits. Another, the K(+)-channel interacting protein KChIP appears critical in formation of native transient outward current (I(to)) channels. The roles of 2 other accessory subunits, the minK-related peptide MiRP and the K(+)-channel accessory protein, KChAP, remain unclear. This article reviews the available knowledge regarding the accessory subunits minK, MiRP, KChIP and KChAP, dealing with their structure, effects on currents carried by coexpressed alpha-subunits, expression in cardiac tissues and potential physiological function. On the basis of the available information, we attempt to assess the potential involvement of these accessory K(+)-channel subunits in cardiac pathophysiology and in developing new therapeutic approaches.
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