ReviewJournal of molecular neuroscience : MN2003
Acetylcholinesterase: a multifaceted target for structure-based drug design of anticholinesterase agents for the treatment of Alzheimer's disease.
Review in Journal of molecular neuroscience : MN, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- Carpoxylon macrospermum leaf extract and its phenolic compounds: a multi-targeted therapeutic remedy for Alzheimer's disease.BMC complementary medicine and therapies · 2026Article
- Organohalogen chalcones: design, synthesis, ADMET prediction, molecular dynamics study and inhibition effect on acetylcholinesterase and carbonic anhydrase.Molecular diversity · 2024Article
- Latest advances in dual inhibitors of acetylcholinesterase and monoamine oxidase B against Alzheimer's disease.Journal of enzyme inhibition and medicinal chemistry · 2023Review
- Restraint Stress Exacerbates Apoptosis in a 6-OHDA Animal Model of Parkinson Disease.Neurotoxicity research · 2023Article
- Explainable machine learning predictions of dual-target compounds reveal characteristic structural features.Scientific reports · 2021Article
- Novel hydroxybenzylamine-deoxyvasicinone hybrids as anticholinesterase therapeutics for Alzheimer's disease.Bioorganic & medicinal chemistry · 2021Article
- Neuroprotective derivatives of tacrine that target NMDA receptor and acetyl cholinesterase - Design, synthesis and biological evaluation.Computational and structural biotechnology journal · 2021Article
- Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor.ACS medicinal chemistry letters · 2020Article
- Article
- Active Site Hydrophobicity and the Convergent Evolution of Paraoxonase Activity in Structurally Divergent Enzymes: The Case of Serum Paraoxonase 1.Journal of the American Chemical Society · 2017Article
- The impact of crystallization conditions on structure-based drug design: A case study on the methylene blue/acetylcholinesterase complex.Protein science : a publication of the Protein Society · 2016Article
- Novel mutations in the amyloid precursor protein gene within Moroccan patients with Alzheimer's disease.Journal of molecular neuroscience : MN · 2014Article
- Diethyl 2-(phenylcarbamoyl)phenyl phosphorothioates: synthesis, antimycobacterial activity and cholinesterase inhibition.Molecules (Basel, Switzerland) · 2014Article
- Dual binding site and selective acetylcholinesterase inhibitors derived from integrated pharmacophore models and sequential virtual screening.BioMed research international · 2014Article
- Multifunctional cholinesterase and amyloid Beta fibrillization modulators. Synthesis and biological investigation.ACS medicinal chemistry letters · 2013Article
- Flavoring extracts of Hemidesmus indicus roots and Vanilla planifolia pods exhibit in vitro acetylcholinesterase inhibitory activities.Plant foods for human nutrition (Dordrecht, Netherlands) · 2013Article
- Acetylcholinesterase-inhibiting activity of salicylanilide N-alkylcarbamates and their molecular docking.Molecules (Basel, Switzerland) · 2012Article
- High throughput enzyme inhibitor screening by functionalized magnetic carbonaceous microspheres and graphene oxide-based MALDI-TOF-MS.Journal of the American Society for Mass Spectrometry · 2011Article
- Interaction of human brain acetylcholinesterase with cyclophosphamide: a molecular modeling and docking study.CNS & neurological disorders drug targets · 2011Article
- 1,3-substituted imidazolidine-2,4,5-triones: synthesis and inhibition of cholinergic enzymes.Molecules (Basel, Switzerland) · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The structure of Torpedo californica acetylcholinesterase is examined in complex with several inhibitors that are either in use or under development for treating Alzheimer's disease. The noncovalent inhibitors vary greatly in their structures and bind to different sites of the enzyme, offering many different starting points for future drug design.
Indexed as
Identifiers
14501022What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.