ArticleJournal of molecular neuroscience : MN2003
Genetic and environmental epidemiology of Alzheimer's disease in arabs residing in Israel.
Article in Journal of molecular neuroscience : MN, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Ethnic Differences in Dementia Diagnosis and Treatment in Israel.Journal of clinical medicine · 2025Article
- Factors Influencing Alzheimer's Disease Risk: Whether and How They are Related to the APOE Genotype.Neuroscience bulletin · 2022Review
- Article
- Who is informed and who uninformed? Addressing the legal barriers to progress in dementia research and care.Israel journal of health policy research · 2019Article
- Ancestral origin of ApoE ε4 Alzheimer disease risk in Puerto Rican and African American populations.PLoS genetics · 2018Article
- 'Evolutionary medicine' perspectives on Alzheimer's Disease: Review and new directions.Ageing research reviews · 2018Review
- Estimating the risk for conversion from mild cognitive impairment to Alzheimer's disease in an elderly Arab community.Journal of Alzheimer's disease : JAD · 2015Article
- Hygiene and the world distribution of Alzheimer's disease: Epidemiological evidence for a relationship between microbial environment and age-adjusted disease burden.Evolution, medicine, and public health · 2013Article
- High APOE epsilon 4 allele frequencies associated with Alzheimer disease in a Tunisian population.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2012Article
- Population Group Differences in Cognitive Functioning in a National Sample of Israelis Fifty Years and Older.Research on aging · 2010Article
- A comparative study to screen dementia and APOE genotypes in an ageing East African population.Neurobiology of aging · 2010Article
- Neuronutrition and Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2010Review
- Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors.The Lancet. Neurology · 2008Review
- Perspective on race and ethnicity in Alzheimer's disease research.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2008Review
- Monoamine oxidase a polymorphism in Brazilian patients: risk factor for late-onset Alzheimer's disease?Journal of molecular neuroscience : MN · 2005Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
We have found an unusually high prevalence of Alzheimer's disease (AD) in Wadi Ara, an inbred Arab community in northern Israel. Allele frequencies of 4.5% and 3.5% were found for the apolipoprotein E e4 allele among AD cases and nondemented controls, respectively, showing that other genetic or environmental influences must be responsible. Family studies revealed that more than one-third of the AD cases are members of one hamula (tribal group) within Wadi Ara. We hypothesize that the high risk of AD in this genetic isolate may be attributable to a founder effect enhanced by consanguinity. It is also possible that smoking or high fat diet are responsible. To map chromosomal loci contributing to AD susceptibility, we conducted a genome scan from specific hamulas and followed candidate regions found to be linked to disease. Markers from 18 chromosomal regions showed significant allelic association with AD. Smoking was very common in men but was not linked to the presence of AD in Wadi Ara, The unique characteristics of this community, together with the large amount of human genome data, should allow for the identification of AD genes in candidate regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.