ArticleNucleic acids research2003
Requirements for selective recruitment of Ets proteins and activation of mb-1/Ig-alpha gene transcription by Pax-5 (BSAP).
Article in Nucleic acids research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Two-way inhibition of PAX5 transcriptional activity by PAX5::CBFA2T3.FEBS open bio · 2025Article
- Biphasic control of the B cell transcriptome by mTORC1 and GSK3.Cell reports · 2025Article
- A novel stroma-dependent leukemia cell line from a patient with mixed-phenotype acute leukemia with Ph chromosome and PAX5 mutation.International journal of hematology · 2025Article
- Establishment of the lymphoid ETS-code reveals deregulated ETS genes in Hodgkin lymphoma.PloS one · 2023Article
- Pax5 mediates the transcriptional activation of the CD81 gene.Scientific reports · 2021Article
- GABPα and CREB1 Binding to Double Nucleotide Polymorphisms of Their Consensus Motifs and Cooperative Binding to the Composite ETS ⇔ CRE Motif (ACS omega · 2019Article
- B Cell Linker Protein (BLNK) Is a Selective Target of Repression by PAX5-PML Protein in the Differentiation Block That Leads to the Development of Acute Lymphoblastic Leukemia.The Journal of biological chemistry · 2016Article
- Article
- The steroidogenic enzyme Cyp11a1 is essential for development of peanut-induced intestinal anaphylaxis.The Journal of allergy and clinical immunology · 2013Article
- A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia.Nature genetics · 2013Article
- Activation of Aicda gene transcription by Pax5 in plasmacytoma cells.Immunologic research · 2013Article
- CD19 is a major B cell receptor-independent activator of MYC-driven B-lymphomagenesis.The Journal of clinical investigation · 2012Article
- The mouse B cell-specific mb-1 gene encodes an immunoreceptor tyrosine-based activation motif (ITAM) protein that may be evolutionarily conserved in diverse species by purifying selection.Molecular biology reports · 2012Article
- Bivalent recognition of nucleosomes by the tandem PHD fingers of the CHD4 ATPase is required for CHD4-mediated repression.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- A strong promoter activity of pre-B cell stage-specific Crlz1 gene is caused by one distal LEF-1 and multiple proximal Ets sites.Molecules and cells · 2011Article
- Article
- Thrombocytopenia in mice lacking the carboxy-terminal regulatory domain of the Ets transcription factor Fli1.Molecular and cellular biology · 2010Article
- Highly cooperative recruitment of Ets-1 and release of autoinhibition by Pax5.Journal of molecular biology · 2009Article
- Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia.The New England journal of medicine · 2009Article
- A role for Fli-1 in B cell proliferation: implications for SLE pathogenesis.Clinical immunology (Orlando, Fla.) · 2008Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Pax-5, a member of the paired domain family of transcription factors, is a key regulator of B lymphocyte-specific transcription and differentiation. A major target of Pax-5-mediated activation is the mb-1 gene, which encodes the essential transmembrane signaling protein Ig-alpha. Pax-5 recruits three members of the Ets family of transcription factors: Ets-1, Fli-1 and GABPalpha (with GABPbeta1), to assemble ternary complexes on the mb-1 promoter in vitro. Using the Pax-5:Ets-1:DNA crystal structure as a guide, we defined amino acid requirements for transcriptional activation of endogenous mb-1 genes using a novel cell-based assay. Mutations in the beta-hairpin/beta-turn of the DNA-binding domain of Pax-5 demonstrated its importance for DNA sequence recognition and activation of mb-1 transcription. Mutations of amino acids contacting Ets-1 in the crystal structure reduced or blocked mb-1 promoter activation. One of these mutations, Q22A, resulted in greatly reduced mb-1 gene transcript levels, concurrent with the loss of its ability to recruit Fli-1 to bind the promoter in vitro. In contrast, the mutation had no effect on recruitment of the related Ets protein GABPalpha (with GABPbeta1). These data further define requirements for Pax-5 function in vivo and reveal the complexity of interactions required for cooperative partnerships between transcription factors.
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