ArticleInfection and immunity2003
Inflammatory cytokine production predominates in early Lyme disease in patients with erythema migrans.
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Trial
- Bridging the gap: Insights in the immunopathology of Lyme borreliosis.European journal of immunology · 2024Review
- Laboratory Diagnosis of Lyme Borreliosis.Clinical microbiology reviews · 2021Review
- Lyme Disease in Humans.Current issues in molecular biology · 2021Article
- Prospective comparison of two enzyme-linked immunosorbent spot assays for the diagnosis of Lyme neuroborreliosis.Clinical and experimental immunology · 2020Article
- Cytokine Expression Patterns and Single Nucleotide Polymorphisms (SNPs) in Patients with Chronic Borreliosis.Antibiotics (Basel, Switzerland) · 2019Article
- Statins reduce spirochetal burden and modulate immune responses in the C3H/HeN mouse model of Lyme disease.Microbes and infection · 2016Article
- Detection of IFN-γ Secretion by T Cells Collected Before and After Successful Treatment of Early Lyme Disease.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016Article
- Natural killer cells and natural killer T cells in Lyme arthritis.Arthritis research & therapy · 2013Article
- Interleukin-10 alters effector functions of multiple genes induced by Borrelia burgdorferi in macrophages to regulate Lyme disease inflammation.Infection and immunity · 2011Article
- TLR1/TLR2 heterodimers play an important role in the recognition of Borrelia spirochetes.PloS one · 2011Article
- Treg cell numbers and function in patients with antibiotic-refractory or antibiotic-responsive Lyme arthritis.Arthritis and rheumatism · 2010Article
- Borrelia burgdorferi stimulation of chemokine secretion by cells of monocyte lineage in patients with Lyme arthritis.Arthritis research & therapy · 2010Article
- Live Borrelia burgdorferi spirochetes elicit inflammatory mediators from human monocytes via the Toll-like receptor signaling pathway.Infection and immunity · 2009Article
- A critical role for type I IFN in arthritis development following Borrelia burgdorferi infection of mice.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Pattern of proinflammatory cytokine induction in RAW264.7 mouse macrophages is identical for virulent and attenuated Borrelia burgdorferi.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- The emergence of Lyme disease.The Journal of clinical investigation · 2004Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
In a study of cytokine production ex vivo by Borrelia burgdorferi-stimulated peripheral blood mononuclear cells from 27 patients with culture-positive erythema migrans, production of inflammatory cytokines predominated, particularly gamma interferon and, to a lesser degree, tumor necrosis factor alpha. In contrast, with the exception of interleukin-13, anti-inflammatory cytokine production was negligible. Thus, B. burgdorferi antigens in early Lyme disease often induce a strong inflammatory response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.