ArticleInfection and immunity2003
The Vsa proteins modulate susceptibility of Mycoplasma pulmonis to complement killing, hemadsorption, and adherence to polystyrene.
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Mycoplasma pneumoniae infections in the Post-COVID era: recent advances from pathogenesis to clinical management.Infection · 2026Review
- Exploring the pangenome of Mycoplasma hyorhinis in search of potential virulence markers.Scientific reports · 2025Article
- Review
- A Review ofFrontiers in veterinary science · 2021Review
- Toll-Like Receptor 2 (TLR2) and TLR4 Mediate the IgA Immune Response Induced by Mycoplasma hyopneumoniae.Infection and immunity · 2019Article
- The mysterious orphans of Mycoplasmataceae.Biology direct · 2016Article
- Type 1 and type 2 strains of Mycoplasma pneumoniae form different biofilms.Microbiology (Reading, England) · 2013Article
- EPS-I polysaccharide protects Mycoplasma pulmonis from phagocytosis.FEMS microbiology letters · 2013Article
- Mycoplasma polysaccharide protects against complement.Microbiology (Reading, England) · 2012Article
- Mycoplasma pulmonis Vsa proteins and polysaccharide modulate adherence to pulmonary epithelial cells.FEMS microbiology letters · 2012Article
- The Vsa shield of Mycoplasma pulmonis is antiphagocytic.Infection and immunity · 2012Article
- Fewer essential genes in mycoplasmas than previous studies suggest.FEMS microbiology letters · 2010Article
- Identification of exopolysaccharide-deficient mutants of Mycoplasma pulmonis.Molecular microbiology · 2009Article
- Mycoplasma biofilms ex vivo and in vivo.FEMS microbiology letters · 2009Article
- Association of Mycoplasma arthritidis mitogen with lethal toxicity but not with arthritis in mice.Infection and immunity · 2008Article
- Large-scale transposon mutagenesis of Mycoplasma pulmonis.Molecular microbiology · 2008Article
- Biofilms protect Mycoplasma pulmonis cells from lytic effects of complement and gramicidin.Infection and immunity · 2007Article
- A stochastic mechanism for biofilm formation by Mycoplasma pulmonis.Journal of bacteriology · 2007Article
- Interactions between mycoplasma lipid-associated membrane proteins and the host cells.Journal of Zhejiang University. Science. B · 2006Review
- Avoidance of the host immune system through phase variation in Mycoplasma pulmonis.Infection and immunity · 2005Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The variable surface antigens (Vsa) of the murine respiratory pathogen Mycoplasma pulmonis are associated with the virulence of the microorganism in the lung. In strain UAB CT, the antigens consist of an N-terminal region that is combined with one of seven different C-terminal variable regions comprised of tandem repeats. M. pulmonis producing a VsaA protein with about 40 tandem repeats (R40) does not adhere to red blood cells or polystyrene. Strains that produce VsaH contain a short C-terminal region that lacks tandem repeats and adhere to red blood cells and plastic. We isolated and analyzed M. pulmonis strain CT variants (CT182 and derivatives) that produced a VsaA protein with only three tandem repeats (R3). These variants adhered to plastic and red blood cells similarly to the VsaH-producing strain. When the R3-producing CT182 strain or the VsaH-producing strains were incubated with normal guinea pig serum, they were efficiently killed. Killing was abolished when the serum was heat inactivated. In contrast, the M. pulmonis strains that produced VsaA R40 were highly resistant to complement killing. CT182R3 variants that survived the complement killing reactions all produced the R40 form of VsaA and were resistant to complement killing. VsaA R40 is the first mycoplasmal protein shown to be associated with resistance to complement. As both VsaH and VsaA can mediate adherence to plastic, cytadherence, and susceptibility to complement, we propose that Vsa modulates these phenotypes by nonspecific interactions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.