ArticleInfection and immunity2003
Deregulated production of protective cytokines in response to Candida albicans infection in patients with chronic mucocutaneous candidiasis.
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 79 citations in OpenAlex.
- Persistent, Asymptomatic Colonization withMicrobiology spectrum · 2022Trial
- Article
- Exposure to long wavelength light that improves aged mitochondrial function shifts acute cytokine expression in serum and the retina.PloS one · 2023Article
- Chronic mucocutaneous candidiasis associated with paracoccidioidomycosis in a patient with mannose receptor deficiency: First case reported in the literature.Revista da Sociedade Brasileira de Medicina Tropical · 2021Article
- IL-1β-MyD88-mTOR Axis Promotes Immune-Protective IL-17AFrontiers in immunology · 2020Article
- HDAC inhibitors modulate innate immune responses to micro-organisms relevant to chronic mucocutaneous candidiasis.Clinical and experimental immunology · 2018Article
- Skin infections are eliminated by cooperation of the fibrinolytic and innate immune systems.Science immunology · 2017Article
- A study on the risk of fungal infection with tofacitinib (CP-690550), a novel oral agent for rheumatoid arthritis.Scientific reports · 2017Article
- Advances in the Care of Primary Immunodeficiencies (PIDs): from Birth to Adulthood.Journal of clinical immunology · 2017Review
- Soluble ST2 in the fetal inflammatory response syndrome: in vivo evidence of activation of the anti-inflammatory limb of the immune response.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2013Article
- Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy.The Journal of clinical and aesthetic dermatology · 2012Article
- Inborn errors of human IL-17 immunity underlie chronic mucocutaneous candidiasis.Current opinion in allergy and clinical immunology · 2012Review
- Inborn errors of mucocutaneous immunity to Candida albicans in humans: a role for IL-17 cytokines?Current opinion in immunology · 2010Review
- Pattern recognition receptor expression is not impaired in patients with chronic mucocutanous candidiasis with or without autoimmune polyendocrinopathy candidiasis ectodermal dystrophy.Clinical and experimental immunology · 2009Article
- Impaired dendritic cell maturation and cytokine production in patients with chronic mucocutanous candidiasis with or without APECED.Clinical and experimental immunology · 2008Article
- The anti-inflammatory limb of the immune response in preterm labor, intra-amniotic infection/inflammation, and spontaneous parturition at term: a role for interleukin-10.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2008Article
- Exogenous farnesol interferes with the normal progression of cytokine expression during candidiasis in a mouse model.Infection and immunity · 2007Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with chronic mucocutaneous candidiasis (CMC) are selectively unable to clear the yeast Candida, which results in persistent debilitating infections affecting the skin, nails, and mucous membranes. The underlying defect is unknown. Recent animal studies highlighted the importance of type 1 cytokines in protection against Candida, and previous work suggested that CMC patients may exhibit altered cytokine production in response to Candida. Based on these findings, in this study we investigated cytokine production in CMC patients by assessing a range of inflammatory, anti-inflammatory, type 1, and type 2 cytokines (interleukin-2 [IL-2], IL-4, IL-5, IL-6, IL-10, IL-12, gamma interferon [IFN-gamma], tumor necrosis factor alpha [TNF-alpha]) in whole-blood cultures in response to five different fractions of Candida albicans (carbohydrate, purified mannan, and protein-rich fractions, etc.), as well as non-Candida antigens. Our results demonstrate that cytokine production is deregulated in a Candida-specific way for some cytokines (IL-2, IL-10), is deregulated more generally for other cytokines (IL-12, IL-6, IFN-gamma), and is not markedly altered for still other cytokines (TNF-alpha, IL-4, IL-5). The most notable finding in CMC patients was the markedly impaired production of IL-12 in parallel with dramatically increased levels of IL-6 and IL-10 that occurred selectively in response to Candida. These results suggest that patients with CMC have impaired production of type 1-inducing cytokines (possibly a macrophage or dendritic cell defect?), which could result in an inability to mount protective cell-mediated responses and a failure to clear Candida. Continued tissue damage and inflammation may trigger production of high levels of inhibitory cytokines, such as the IL-10 production seen in our study, which would further reduce production of type 1-inducing cytokines in a positive feedback loop leading to persistent infection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.